全谷物调节代谢性疾病机制研究的新视角——肠道微生物

龚凌霄; 曹文燕; 王静; 张慧娟; 刘英丽

doi:10.13386/j.issn1002-0306.2017.02.062

全谷物调节代谢性疾病机制研究的新视角——肠道微生物

北京工商大学,北京食品营养与人类健康高精尖创新中心,食品添加剂与配料北京高校工程研究中心

基金项目:

国家自然科学基金项目(31501480,31571940,31271976)；

详细信息

作者简介:
龚凌霄(1981-),女,博士,讲师,研究方向:天然产物与功能性食品,E-mail:gonglingxiao@btbu.edu.cn。;

王静(1976-),女,博士,教授,研究方向:功能性食品配料,E-mail:wangjing@th.btbu.edu.cn。;

中图分类号: R151
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出版历程
- 收稿日期: 2016-06-27

The gut microbiota-targeted whole cereal grain intake and its mechanism in ameliorating metabolic diseases

Beijing Advanced Innovation Center for Food Nutrition and Human Health,Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients,Beijing Technology & Business University (BTBU)

摘要

摘要: 全谷物中含有丰富的植物化学素和多种营养成分,增加全谷物的摄入能够显著降低代谢性疾病(如肥胖、Ⅱ型糖尿病)的发生率,然而也正是由于全谷物成分复杂,很多现有的体外研究模型和方法并不适用于全谷物保健机制的研究。随着肠道微生物与人体健康之间的关系逐步得到揭示,肠道微生物启发了全谷物健康保健机制的研究方向。本文将详细介绍肠道微生物与代谢性疾病、全谷物成分与肠道微生物以及全谷物与肠道微生物之间的研究现状,并分析以肠道微生物作为全谷物保健机制研究靶点的可行性,目的在于为明确健康作用的全谷物及其相关产品的综合开发提供研究思路,使得来源广泛、食用方便、功效显著的全谷物更好地服务于人类健康。
- 全谷物 /
- 肠道微生物 /
- 代谢性疾病 /
- 肥胖
Abstract: A large body of scientific researches has shown the inverse relationship between consumption of whole cereal grains and occurrences of metabolic diseases. Due to the complicated ingredients,which may show synergistic action to mediate the protective effects,the conventional methods are not appropriate to clarify the mechanisms for whole grains on health promotion.Meanwhile,gut microbiota is closely related to human health,which is probably modulated by diet intervention. Thus,research has been increasingly focusing on the potential of ingredients present in whole cereal grains to steer gut microbiota activity and composition in a beneficial way. In this review,special interest will be directed to gut microbiota,whole cereal grains and metabolic disease.The results may bring a new way to elucidate the mechanism of whole cereal grain in ameliorating metabolic diseases.As results,the gut microbiota- targeted whole cereal grain intake will serve for human health better.
- whole cereal grain /
- gut microbiota /
- metabolic disease /
- obesity

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