全谷物调节代谢性疾病机制研究的新视角——肠道微生物

龚凌霄; 曹文燕; 王静; 张慧娟; 刘英丽

doi:10.13386/j.issn1002-0306.2017.02.062

全谷物调节代谢性疾病机制研究的新视角——肠道微生物

北京工商大学,北京食品营养与人类健康高精尖创新中心,食品添加剂与配料北京高校工程研究中心

基金项目:

国家自然科学基金项目(31501480,31571940,31271976)；

详细信息

作者简介:
龚凌霄(1981-),女,博士,讲师,研究方向:天然产物与功能性食品,E-mail:gonglingxiao@btbu.edu.cn。;

王静(1976-),女,博士,教授,研究方向:功能性食品配料,E-mail:wangjing@th.btbu.edu.cn。;

中图分类号: R151
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出版历程
- 收稿日期: 2016-06-27

The gut microbiota-targeted whole cereal grain intake and its mechanism in ameliorating metabolic diseases

Beijing Advanced Innovation Center for Food Nutrition and Human Health,Beijing Higher Institution Engineering Research Center of Food Additives and Ingredients,Beijing Technology & Business University (BTBU)

摘要

摘要: 全谷物中含有丰富的植物化学素和多种营养成分,增加全谷物的摄入能够显著降低代谢性疾病(如肥胖、Ⅱ型糖尿病)的发生率,然而也正是由于全谷物成分复杂,很多现有的体外研究模型和方法并不适用于全谷物保健机制的研究。随着肠道微生物与人体健康之间的关系逐步得到揭示,肠道微生物启发了全谷物健康保健机制的研究方向。本文将详细介绍肠道微生物与代谢性疾病、全谷物成分与肠道微生物以及全谷物与肠道微生物之间的研究现状,并分析以肠道微生物作为全谷物保健机制研究靶点的可行性,目的在于为明确健康作用的全谷物及其相关产品的综合开发提供研究思路,使得来源广泛、食用方便、功效显著的全谷物更好地服务于人类健康。
- 全谷物 /
- 肠道微生物 /
- 代谢性疾病 /
- 肥胖
Abstract: A large body of scientific researches has shown the inverse relationship between consumption of whole cereal grains and occurrences of metabolic diseases. Due to the complicated ingredients,which may show synergistic action to mediate the protective effects,the conventional methods are not appropriate to clarify the mechanisms for whole grains on health promotion.Meanwhile,gut microbiota is closely related to human health,which is probably modulated by diet intervention. Thus,research has been increasingly focusing on the potential of ingredients present in whole cereal grains to steer gut microbiota activity and composition in a beneficial way. In this review,special interest will be directed to gut microbiota,whole cereal grains and metabolic disease.The results may bring a new way to elucidate the mechanism of whole cereal grain in ameliorating metabolic diseases.As results,the gut microbiota- targeted whole cereal grain intake will serve for human health better.
- whole cereal grain /
- gut microbiota /
- metabolic disease /
- obesity

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参考文献(49)

[1]	Okarter N,Liu R H.Health benefits of whole grain phytochemicals[J].Critical Reviews in Food Science and Nutrition,2010,50(3):193-208.
[2]	Lamsal B P,Faubion J M.The beneficial use of cereal and cereal components in probiotic foods[J].Food Reviews International,2009,25(2):103-114.
[3]	Nicholson J K,Holmes E,Lindon J C,et al.The challenges of modeling mammalian biocomplexity[J].Nature Biotechnology,2004,22(10):1268-1274.
[4]	陈卫.肠道菌群:膳食与健康研究的新视角[J].食品科学技术学报,2015,33(6):1-6.
[5]	Roberfroid M B,Bornet F,Bouley C,et al.Colonic microflora:nutrition and health.Summary and conclusions of an International Life Sciences Institute(ILSI)[Europe]workshop held in Barcelona,Spain[J].Nutrition Reviews,1995,53(5):127-130.
[6]	Samuel B S,Shaito A,Motoike T,et al.Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor,Gpr41[J].Proceedings of the National Academy of Sciences,2008,105(43):16767-16772.
[7]	Dewulf E M,Cani P D,Neyrinck A M,et al.Inulin-type fructans with prebiotic properties counteract GPR43overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice[J].The Journal of Nutritional Biochemistry,2011,22(8):712-722.
[8]	Bckhed F,Ding H,Wang T,et al.The gut microbiota as an environmental factor that regulates fat storage[J].Proceedings of the National Academy of Sciences of the United States of America,2004,101(44):15718-15723.
[9]	Bckhed F,Manchester J K,Semenkovich C F,et al.Mechanisms underlying the resistance to diet-induced obesity ingerm-free mice[J].Proceedings of the National Academy of Sciences of the United States of America,2007,104(3):979-984.
[10]	Cani P D,Amar J,Iglesias M A,et al.Metabolic endotoxemia initiates obesity and insulin resistance[J].Diabetes,2007,56(7):1761-1772.
[11]	Cerf-Bensussan N,Gaboriau-Routhiau V.The immune system and the gut microbiota:friends or foes?[J].Nature Reviews Immunology,2010,10(10):735-744.
[12]	赵兰涛,程李琳,张晖,等.不同谷物对小鼠肠道菌群的影响[J].粮食与食品工业,2013,20(5):51-55.
[13]	孙元琳,陕方,赵立平.谷物膳食纤维——戊聚糖与肠道菌群调节研究进展[J].食品科学,2012,33(9):326-330.
[14]	Tremaroli V,Bckhed F.Functional interactions between the gut microbiota and host metabolism[J].Nature,2012,489(7415):242-249.
[15]	Hughes S A,Shewry P R,Li L,et al.In vitro fermentation by human fecal microflora of wheat arabinoxylans[J].Journal of Agricultural and Food Chemistry,2007,55(11):4589-4595.
[16]	Cani P D,Possemiers S,Van de Wiele T,et al.Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability[J].Gut,2009,58(8):1091-1103.
[17]	Neyrinck A M,Possemiers S,Druart C,et al.Prebiotic effects of wheat arabinoxylan related to the increase in bifidobacteria,Roseburia and Bacteroides/Prevotella in diet-induced obese mice[J].PLo S One,2011,6(6):e20944.
[18]	Vardakou M,Palop C N,Gasson M,et al.In vitro three-stage continuous fermentation of wheat arabinoxylan fractions and induction of hydrolase activity by the gut microflora[J].International Journal of Biological Macromolecules,2007,41(5):584-589.
[19]	Rose D J,Patterson J A,Hamaker B R.Structural differences among alkali-soluble arabinoxylans from maize(Zea mays),rice(Oryza sativa),and wheat(Triticum aestivum)brans influence human fecal fermentation profiles[J].Journal of Agricultural and Food Chemistry,2009,58(1):493-499.
[20]	Van den Abbeele P,Venema K,Van de Wiele T,et al.Different human gut models reveal the distinct fermentation patterns of arabinoxylan versus inulin[J].Journal of Agricultural and Food Chemistry,2013,61(41):9819-9827.
[21]	Geraylou Z,Souffreau C,Rurangwa E,et al.Effects of arabinoxylan-oligosaccharides(AXOS)on juvenile Siberian sturgeon(Acipenser baerii)performance,immune responses and gastrointestinal microbial community[J].Fish&Shellfish Immunology,2012,33(4):718-724.
[22]	Neyrinck A M,Van Hee V F,Piront N,et al.Wheat-derived arabinoxylan oligosaccharides with prebiotic effect increase satietogenic gut peptides and reduce metabolic endotoxemia in diet-induced obese mice[J].Nutrition&Diabetes,2012,2(1):e28.
[23]	申瑞玲,朱莹莹,李林,等.燕麦β-葡聚糖调节肠道菌群与降脂减肥作用的研究进展[J].食品工业科技,2014,35(8):364-366.
[24]	Metzler-Zebeli B U,Zebeli Q.Cerealβ-glucan alters nutrient digestibility and microbial activity in the intestinal tract of pigs,and lower manure ammonia emission:A meta-analysis[J].Journal of Animal Science,2013,91(7):3188-3199.
[25]	Mitsou E K,Panopoulou N,Turunen K,et al.Prebiotic potential of barley derivedβ-glucan at low intake levels:a randomised,double-blinded,placebo-controlled clinical study[J].Food Research International,2010,43(4):1086-1092.
[26]	Hughes S A,Shewry P R,Gibson G R,et al.In vitro fermentation of oat and barley derivedβ-glucans by human faecal microbiota[J].FEMS Microbiology Ecology,2008,64(3):482-493.
[27]	Wang Y,Ames N P,Tun H M,et al.High molecular weight barleyβ-glucan alters gut microbiota toward reduced cardiovascular disease risk[J].Frontiers in Microbiology,2016,7(e28472).
[28]	Nugent A P.Health properties of resistant starch[J].Nutrition Bulletin,2005,30(1):27-54.
[29]	Topping D L,Fukushima M,Bird A R.Resistant starch as a prebiotic and synbiotic:state of the art[C]//Proceedingsnutrition Society of London.CABI Publishing,1999,62(1):171-176.
[30]	方建东.抗性淀粉对小鼠肠道菌群的影响极以及作用机制的研究[D].杭州:浙江工商大学,2014.
[31]	Dahl W J,Ford A L,Ukhanova M,et al.Resistant potato starches(type 4 RS)exhibit varying effects on laxation with and without phylum level changes in microbiota:A randomised trial in young adults[J].Journal of Functional Foods,2016,23:1-11.
[32]	Walker A W,Ince J,Duncan S H,et al.Dominant and dietresponsive groups of bacteria within the human colonic microbiota[J].The ISME Journal,2011,5(2):220-230.
[33]	Liu R H.Whole grain phytochemicals and health[J].Journal of Cereal Science,2007,46(3):207-219.
[34]	Adom K K,Liu R H.Antioxidant activity of grains[J].Journal of Agricultural and Food Chemistry,2002,50(21):6182-6187.
[35]	Valdés L,Cuervo A,Salazar N,et al.The relationship between phenolic compounds from diet and microbiota:impact on human health[J].Food&Function,2015,6(8):2424-2439.
[36]	杨华,叶发银,赵国华.膳食多酚与肠道微生物相互作用研究进展[J].食品科学,2015(3):223-227.
[37]	Zhang X,Yang Y,Wu Z,et al.The Modulatory Effect of Anthocyanins from Purple Sweet Potato on Human Intestinal Microbiota in vitro[J].Journal of Agricultural and Food Chemistry,2016,64(12):2582-2590.
[38]	Parkar S G,Trower T M,Stevenson D E.Fecal microbial metabolism of polyphenols and its effects on human gut microbiota[J].Anaerobe,2013,23:12-19.
[39]	Lee H C,Jenner A M,Low C S,et al.Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota[J].Research in Microbiology,2006,157(9):876-884.
[40]	Parkar S G,Stevenson D E,Skinner M A.The potential influence of fruit polyphenols on colonic microflora and human gut health[J].International Journal of Food Microbiology,2008,124(3):295-298.
[41]	Yuan X,Wang J,Yao H.Feruloyl oligosaccharides stimulate the growth of Bifidobacterium bifidum[J].Anaerobe,2005,11(4):225-229.
[42]	Benno Y,Endo K,Miyoshi H,et al.Effect of rice fiber on human fecal microflora[J].Microbiology and Immunology,1989,33(5):435-440.
[43]	Vitaglione P,Mennella I,Ferracane R,et al.Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors:role of polyphenols bound to cereal dietary fiber[J].The American Journal of Clinical Nutrition,2015,101(2):251-261.
[44]	Lappi J,Salojrvi J,Kolehmainen M,et al.Intake of wholegrain and fiber-rich rye bread versus refined wheat bread does not differentiate intestinal microbiota composition in Finnish adults with metabolic syndrome[J].The Journal of Nutrition,2013,143(5):648-655.
[45]	赵兰涛.全谷物对肠道菌群益生作用的研究[D].无锡:江南大学,2013.
[46]	Costabile A,Klinder A,Fava F,et al.Whole-grain wheat breakfast cereal has a prebiotic effect on the human gut microbiota:a double-blind,placebo-controlled,crossover study[J].British Journal of Nutrition,2008,99(1):110-120.
[47]	Yang J,Keshavarzian A,Rose D J.Impact of dietary fiber fermentation from cereal grains on metabolite production by the fecal microbiota from normal weight and obese individuals[J].Journal of Medicinal Food,2013,16(9):862-867.
[48]	Aumiller T,Mosenthin R,Weiss E.Potential of cereal grains and grain legumes in modulating pigs’intestinal microbiota-A review[J].Livestock Science,2015,172:16-32.
[49]	Zhong Y,Marungruang N,Fk F,et al.Effects of two wholegrain barley varieties on caecal SCFA,gut microbiota and plasma inflammatory markers in rats consuming low-and high-fat diets[J].British Journal of Nutrition,2015,113(10):1558-1570.