• EI
  • Scopus
  • 中国科技期刊卓越行动计划项目资助期刊
  • 北大核心期刊
  • DOAJ
  • EBSCO
  • 中国核心学术期刊RCCSE A+
  • 中国精品科技期刊
  • JST China
  • FSTA
  • 中国农林核心期刊
  • 中国科技核心期刊CSTPCD
  • CA
  • WJCI
  • 食品科学与工程领域高质量科技期刊分级目录第一方阵T1
中国精品科技期刊2020

食源性钙结合多肽的研究进展

孙殿钦, 吕晨艳

孙殿钦, 吕晨艳. 食源性钙结合多肽的研究进展[J]. 食品工业科技, 2016, (24): 386-390. DOI: 10.13386/j.issn1002-0306.2016.24.067
引用本文: 孙殿钦, 吕晨艳. 食源性钙结合多肽的研究进展[J]. 食品工业科技, 2016, (24): 386-390. DOI: 10.13386/j.issn1002-0306.2016.24.067
SUN Dian-qin, LV Chen-yan. Research progress of calcium-binding peptides from foodstuffs[J]. Science and Technology of Food Industry, 2016, (24): 386-390. DOI: 10.13386/j.issn1002-0306.2016.24.067
Citation: SUN Dian-qin, LV Chen-yan. Research progress of calcium-binding peptides from foodstuffs[J]. Science and Technology of Food Industry, 2016, (24): 386-390. DOI: 10.13386/j.issn1002-0306.2016.24.067

食源性钙结合多肽的研究进展

基金项目: 

首都医科大学优秀青年教师国内交流项目;

详细信息
    作者简介:

    孙殿钦(1996-),男,大学本科,研究方向:食品营养,E-mail:mr_sped@126.com。;

    吕晨艳(1988-),女,博士,讲师,研究方向:食品营养,E-mail:lvchenyan1010@163.com。;

  • 中图分类号: TS218

Research progress of calcium-binding peptides from foodstuffs

  • 摘要: 钙是维持人体生命活动所必需的常量元素。然而,我国居民膳食中钙的摄入量仅为推荐摄入量的一半,传统补钙制剂存在生物利用率低等缺点,因此开发安全高效的补钙制剂势在必行。食源性钙结合多肽因其天然性更为安全可靠,越来越成为研究的热点。本文对常见的食源性钙结合多肽及其分离纯化、鉴定方法进行综述,以寻找食源性钙结合多肽的新路径,以期为食源性钙结合多肽的制备和开发提供参考。 
    Abstract: Calcium is an essential element of the human body,and plays a significant role in health. However,the dietary intake of calcium in China is only half of the recommended intakes. Considering the low bioavailability of traditional calcium supplements,developing the safe and efficient calcium supplements is imperative. Calcium-binding peptides from foodstuffs are safer and more reliable,which have caused the extensive concern of researchers.In this review,several typical calcium- binding peptides from foodstuffs,and methods of purification,identification and structural analysis had been summarized,which would provide reference for the application of calcium- binding peptides in functional food.
  • [1]

    Wang Y,Tao Y X,Hyman M E,et al.Osteoporosis in china[J].Osteoporosis International,2009,20(10):1651-1662.

    [2] 中华人民共和国国家卫生和计划生育委员会.中国居民营养与慢性病状况报告(2015年)[R].北京:中华人民共和国国务院新闻办公室,2015.
    [3] 薛荣涛,李翠芹,何腊平.复合氨基酸螯合钙的研究进展[J].食品工业科技,2014,35(21):390-394.
    [4] 蒋金来,王令充,吴皓,等.钙制剂研究进展[J].食品工业科技,2012,33(11):379-382,387.
    [5] 陈锦瑶,张立实.生物活性肽的安全性评价研究进展[J].毒理学杂志,2013(2):142-146.
    [6]

    Bouhallab S D,Bougl D.Biopeptides of milk:Caseinophosphopeptides and mineral bioavailability[J].Reproduction Nutrition Development,2004,44(5):493-498.

    [7]

    Mekmene O,Gaucheron F.Determination of calcium-binding constants of caseins,phosphoserine,citrate and pyrophosphate:A modelling approach using free calcium measurement[J].Food Chemistry,2011,127(2):676-682.

    [8]

    Perego S,Del F E,De Luca P,et al.Calcium bioaccessibility and uptake by human intestinal like cells following in vitro digestion of casein phosphopeptide-calcium aggregates[J].Food&Function,2015,6(6):1796-1807.

    [9]

    Ryuichiro S,Masanori S,Hiromi G,et al.Characterization of phosphopeptide derived from bovineβ-casein:An inhibitor to intra-intestinal precipitation of calcium phosphate[J].Biochimicaet Biophysica Acta,1991,1077(3):413-415.

    [10]

    Silvia P,Stefania C,Amelia F,et al.Casein phosphopeptides modulate proliferation and apoptosis in HT-29 cell line through their interaction with voltage-operated L-type calcium channels[J].Journal of Nutritional Biochemistry,2012,23(7):808-816.

    [11]

    Teucher B,Majsak-Newman G,Dainty J R,et al.Calcium absorption is not increased by caseinophosphopeptides[J].American Journal of Clinical Nutrition,2006,84(1):162-166.

    [12]

    Marvin M H,Brittmarie S,Michael F J,et al.Casein phosphopeptides improve zinc and calcium absorption from ricebased but not from whole-grain infant cereal.[J].Journal of Pediatric Gastroenterology and Nutrition,1997,24(1):56-62.

    [13]

    Hong Z,Lijuan P,Saisai Z,et al.Effects of molecular structure on the calcium-binding properties of phosphopeptides[J].European Food Research and Technology,2012,235(5):811-816.

    [14]

    Daniela E,Salvatore C,Giulio T.Effect of the ratio of casein phosphopeptides to calcium(w/w)on passive calcium transport in the distal small intestine of rats[J].Nutrition,2002,18(9):743-746.

    [15]

    Divya P,A J L.Preparation of caseinophosphopeptides and assessing their efficacy in enhancing the bioaccessibility of iron and zinc[J].Journal of Food Science and Technology-Mysore,2015,52(11):7493-7499.

    [16] 谢玮,宫学诗.酪蛋白磷酸肽的毒性研究[J].预防医学文献信息,2003,9(5):573-574.
    [17]

    Bm B,Adv S,Jam V,et al.Amino-acid-sequence of phosvitin derived from the nucleotide-sequence of part of the chicken vitellogenin gene[J].Biochemistry,1984,23(19):4275-4279.

    [18]

    Satoshi I,Shigeru T,Keizo A,et al.Egg yolk protein and egg yolk phosvitin inhibit calcium,magnesium,and iron absorptions in rats[J].Journal of Food Science,2007,72(6):S412.

    [19] 王飞,刘静波,林松毅,等.卵黄高磷蛋白磷酸肽-钙对受试小鼠钙表观吸收率的影响[J].食品科学,2008,29(12):654-657.
    [20]

    Jiang B,Mine Y.Phosphopeptides derived from hen egg yolk phosvitin:Effect of molecular size on the calcium-binding properties[J].Biosci Biotechnol Biochem,2001,65(5):1187-1190.

    [21]

    Anton M,Castellani O,Guérin-Dubiard C.Phosvitin[M].Berlin,Heidelberg:Springer Berlin Heidelberg,2007:17-24.

    [22]

    Charoenphun N,Cheirsilp B,Sirinupong N,et al.Calciumbinding peptides derived from tilapia(Oreochromis niloticus)protein hydrolysate[J].European Food Research and Technology,2013,236(1):57-63.

    [23]

    Lv Y,Bao X L,Yang B C,et al.Effect of soluble soybean protein Hydrolysate-Calcium complexes on calcium uptake by caco-2 cells[J].Journal of Food Science,2008,73(7):H168-H173.

    [24]

    Kumagai H,Koizumi A,Suda A,et al.Enhanced calcium absorption in the small intestine by a phytate-removed deamidated soybean globulin preparation[J].Bioscience,Biotechnology,and Biochemistry,2004,68(7):1598-1600.

    [25]

    Lv Y,Liu H,Ren J,et al.The positive effect of soybean protein hydrolysates—calcium complexes on bone mass of rapidly growing rats[J].Food&Function,2013,4(8):1245-1251.

    [26]

    Lv Y,Bao X L,Liu H,et al.Purification and characterization of caclium-binding soybean protein hydrolysates by Ca2+/Fe3+immobilized metal affinity chromatography(IMAC)[J].Food Chemistry,2013,141(3):1645-1650.

    [27]

    Liu H,Lv Y,Xu J T,et al.Soybean peptide aggregates improved calcium binding capacity[J].LWT-Food Science and Technology,2016,67:174-180.

    [28]

    Jung W,Lee B,Kim S.Fish-bone peptide increases calcium solubility and bioavailability in ovariectomised rats[J].British Journal of Nutrition,2006,95(1):124.

    [29]

    Chen D,Mu X,Huang H,et al.Isolation of a calciumbinding peptide from tilapia scale protein hydrolysate and its calcium bioavailability in rats[J].Journal of Functional Foods,2014,6:575-584.

    [30] 黄海,李八方,刘尊英,等.鱼卵肽钙复合物对大鼠体内促钙吸收作用的研究[J].食品工业科技,2014,35(3):331-335.
    [31]

    Huang S L,Zhao L N,Cai X X,et al.Purification and characterisation of a glutamic acid-containing peptide with calcium-binding capacity from whey protein hydrolysate[J].Journal of Dairy Research,2015,82(1):29-35.

    [32]

    Jihye L,Dongwon C,Kyungbin S.Isolation of CalciumBinding Peptides from Barley Protein Hydrolysates[J].2012,19(3):438-442.

    [33]

    Dongwon C,Jihye L,Hohyun C,et al.Isolation of a calciumbinding peptide from bovine serum protein hydrolysates[J].Food Science and Biotechnology,2012,21(6):1663-1667.

    [34] 吕晨艳,赵广华.葡萄籽中水溶性钙结合蛋白的分离和鉴定[J].农业工程学报,2015(2):319-323.
    [35]

    Yang H X,Zhang T,Masuda T,et al.Chitinase III in pomegranate seeds(Punica granatum Linn.):A high-capacity calcium-binding protein in amyloplasts[J].The Plant Journal,2011,68(5):765-776.

    [36]

    Huang G,Ren L,Jiang J.Purification of a histidinecontaining peptide with calcium binding activity from shrimp processing byproducts hydrolysate[J].European Food Research and Technology,2011,232(2):281-287.

    [37]

    Jung W,Karawita R,Heo S,et al.Recovery of a novel Cabinding peptide from Alaska Pollack(Theragra chalcogramma)backbone by pepsinolytic hydrolysis[J].Process Biochemistry,2006,41(9):2097-2100.

    [38]

    Jung W,Kim S.Calcium-binding peptide derived from pepsinolytic hydrolysates of hoki(Johnius belengerii)frame[J].European Food Research and Technology,2007,224(6):763-767.

    [39]

    Guo L,Harnedy P A,O Keeffe M B,et al.Fractionation and identification of Alaska pollock skin collagen-derived mineral chelating peptides[J].Food Chemistry,2015,173:536-542.

    [40]

    Huang H,Li B F,Liu Z Y,et al.Purification of a novel oligophosphopeptide with high calcium binding activity from carp egg hydrolysate[J].Food Science and Technology Research,2014,20(4):799-807.

    [41] 彭莉娟,王伟,张赛赛,等.基于模拟酶切的酪蛋白定向酶解探究[J].食品工业科技,2012,33(3):214-216.
    [42]

    Raus M,Kopecny D,ebela M.Program application for the prediction of results of protein digestion by proteolytic enzymes[J].Chemicke Listy,2013,107(1):44-53.

    [43]

    Zhang J,Sun J,Liu Y T,et al.Separation and purification of phosvitin phosphopeptides using immobilized metal affinity nanoparticles[J].Journal of Chromatography B,2012,893-894:121-126.

    [44]

    Guo L D,Harnedy P A,Li B F,et al.Food protein-derived chelating peptides:Biofunctional ingredients for dietary mineral bioavailability enhancement[J].Trends in Food Science&Technology,2014,37(2):92-105.

    [45]

    Lahrichi S L,Affolter M,Zolezzi I S,et al.Food Peptidomics:Large scale analysis of small bioactive peptides—a pilot study[J].Journal of Proteomics,2013,88:83-91.

    [46]

    Ren J D,Li Q Y,Offengenden M,et al.Preparation and characterization of phosphopeptides from egg yolk phosvitin[J].Journal of Functional Foods,2015,18:190-197.

    [47] 于志鹏,薛如阳,赵文竹,等.肽组学在食源性活性肽研究中应用的进展[J].食品工业科技,2016(4):382-385.
    [48] 邹平,何国庆,吴建平.基于生物信息学,qsar及分子对接的菜籽ace抑制肽筛选[J].食品工业科技,2014(17):71-74.
    [49]

    West D W.Structure and function of the phosphorylated residues of casein[J].Journal of Dairy Research,1986,53(2):333-352.

    [50]

    Bao X L,Lv Y,Yang B C,et al.A study of the soluble complexes formed during calcium binding by soybean protein hydrolysates[J].Journal of Food Science,2008,73(3):C117-C121.

计量
  • 文章访问数: 
  • HTML全文浏览量: 
  • PDF下载量: 
  • 被引次数: 0
出版历程
  • 收稿日期:  2016-07-07

目录

    /

    返回文章
    返回
    x 关闭 永久关闭