Overview on anti-tumor mechanism and effect of diosmin
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摘要: 香叶木苷又名地奥司明(Diosmin),在多种药食同源的天然植物中含量丰富,其作用于动静脉系统的药理学活性被广泛报道,其可抑制肿瘤细胞增殖,对癌细胞具有特异性促凋亡活性和化学预防作用,因而被认为是有潜质的抗肿瘤药物。本文将香叶木苷对肿瘤细胞的增殖与凋亡、信号通路、抗多药耐药等方面的机制作以综述。Abstract: Diosmin,a naturally occurring flavonoid compounds,which is found abundantly in various natural plants and citrus fruits.It has shown a broad range of pharmacological activities in arterial and venous systems.Recently the inhibitory effect on proliferation of tumor cell was reported extensively. Since its pro- apoptotic activity and chemical prevention effect,which was considered to be a potential anti- tumor drug.In this paper,it was reviewed the mechanisms progress of diosmin on tumor cells proliferation and apoptosis,signal pathway,anti- multidrug resistance.
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Keywords:
- diosmin /
- antitumor /
- mechanisms
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[1] 李文哲,巩龙,王霖,等.地奥司明的药理活性研究进展[J].中国疗养医学,2012,21(10):887-888. [2] H Ciolino,T Wang,G Yeh.Diosmin and Diosmetin Are Agonists of the Aryl Hydrocarbon Receptor That Differentially Affect Cytochrome P450 1A1 Activity[J].Cancer Research,1998,58(13):2754-2760.
[3] 陈伟兰,钟惠青,卢秋桃.地奥司明的药理活性研究进展[J].基层医学论坛,2012,16(4):515-516. [4] 马英丽,卢卫红,于晓敏,等.蓬子菜的化学成分研究(I)[J].中草药,2005,36(10):1464-1466. [5] D Cova,A L De,F Giavarini,et al.Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis.[J].J Clin Pharm Thera&Toxi,1992,30(1):29-33.
[6] K A Lyseng Williamson,C M Perry.Micronised purified flavonoid fraction:a review of its use in chronic venous insufficiency,venous ulcers and haemorrhoids[J].Drugs,2003,63(2):71-100.
[7] 黎凤明,田晓东,胡国文,等.地奥司明的药理活性研究进展[J].现代中西医结合杂志,2012,21(6):680-681. [8] S Kuntz,U Wenzel,H Daniel.Comparative analysis of the effects of flavonoids on proliferation,cytotoxicity,and apoptosis in human colon cancer cell lines[J].J Nutri,1999,38(3):133-142.
[9] Y Y Xie,D Yuan,J Y Yang,et al.Cytotoxic activity of flavonoids from the flowers of Chrysanthemum morifolium on human colon cancer Colon205 cells[J].J Asian Natu Prod Res,2009,11(9):771-778.
[10] S L Dholakiya,K E.Protective effect of diosmin on LPSinduced apoptosis in PC12 cells and inhibition of TNF-αexpression[J].Toxicol in Vitr,2011,25(5):1039-1044.
[11] H H Arab,S A Salama,H A Omar,et al.Diosmin protects against ethanol-induced gastric injury in rats:novel anti-ulcer actions[J].Plos One,2014,36(10):893-896.
[12] S Kobayashi,S Tanabe,M Sugiyama,et al.Transepithelial transport of hesperetin and hesperidin in intestinal Caco-2 cell monolayers[J].Biochimicaet Biophysica Acta,2008,1778(1):33-41.
[13] T Tanaka,H Makita,M Ohnishi,et al.Chemoprevention of4-Nitroquinoline 1-Oxide-induced Oral Carcinogenesis in Rats by Flavonoids Diosmin and Hesperidin,Each Alone and in Combination[J].Cancer Res,1997,57(2):246-252.
[14] Y Y Xie,D Yuan,J Y Yang,et al.Cytotoxic activity of flavonoids from the flowers of Chrysanthemum morifolium on human colon cancer Colon205 cells[J].J Asian Natu Prod Res,2009,11(9):771-778.
[15] 于新颖,文翠菊,孙红娟,等.对乳腺癌相关淋巴水肿患者结局影响的调查[J].中华现代护理杂志,2013,19(27):3318-3321. [16] 刘宁宁.地奥司明(DOSM)对Hep G2肝癌细胞诱导分化作用的研究[D].北京:首都师范大学,2009. [17] M Tahir,M U Rehman,A Lateef,et al.Diosmin abrogates chemically induced hepatocarcinogenesis via alleviation of oxidative stress,hyperproliferative and inflammatory markers in murine model[J].Toxico Lett,2013,220(3):205-218.
[18] M Malumbres,M Barbacid.Cell cycle,CDKs and cancer:a changing paradigm[J].Nat Rev Cancer,2009,9(3):153-166.
[19] J V Forment,M Blasius,I Guerini,et al.Structure-specific DNA endonuclease Mus81/Eme1 generates DNA damage caused by Chk1 inactivation[J].Plos One,2011,6(8):e23517-e23517.
[20] E Manchado,M Guillamot,C G De,et al.Targeting mitotic exit leads to tumor regression in vivo:Modulation by Cdk1,Mastl,and the PP2A/B55α,δphosphatase.[J].Cancer Cell,2010,18(6):641-654.
[21] D Tran Duc,C H Day,B Truong Viet,et al.PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K-Akt-MDM2signaling suppression[J].Food Chem Toxicol,2012,50(5):1802-1810.
[22] N Nagasundaram,H Zhu,J Liu,et al.Analysing the Effect of Mutation on Protein Function and Discovering Potential Inhibitorsof CDK4:Molecular Modelling and Dynamics Studies[J].Plos One,2015,10(8).
[23] S H Rostami,S Abroun,K Alimoghaddam,et al.Arsenic trioxide-induced apoptosis in HL-60 cell line by decreasing the ratio of Bcl-2 to Bax mRNA expression[J].Scientific Journal of Iranian Blood Transfusion Organization,2013.
[24] LIU Xia,ZHANG Jianxiang,ZHANG Jian,et al.Diosmin protects against cerebral ischemia/reperfusion injury through activating JAK2/STAT3 signal pathway in mice[J].Neurosci,2014,268(21):318-327.
[25] A Lewinska,J Siwak,I Rzeszutek,et al.Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line[J].Toxi--col in Vitr,2015,29(3):417-425.
[26] K Bhaskar,S B Marquez,K W Thompson,et al.Flavonoids from each of the six structural groups reactivate BRM,a possible cofactor for the anticancer effects of flavonoids[J].Carcinogenesis,2014,35(10):2183-2193.
[27] H H Yoo,M Lee,H J Chung,et al.Effects of diosmin,a flavonoid glycoside in citrus fruits,on P-glycoprotein-mediated drug efflux in human intestinal Caco-2 cells[J].J Agric Food Chem,2007,55(18):7620-7625.
[28] K Rajnarayana,A Venkatesham,D R Krishna.Influence of Some Bioflavonoids on Transport of Nitrendipine.[J].Drug Meta&Drug Interactions,2008,23(3-4):299-310.
[29] 胡大裕.表面活性剂对肿瘤细胞多药耐药的逆转作用[D].武汉:华中科技大学,2006. [30] M U Rehman,M Tahir,K A Quaiyoom,et al.Diosmin protects against trichloroethylene-induced renal injury in Wistar rats:pla--usible role of p53,Bax and caspases[J].Br J Nutr,2013,110(4):699-710.
[31] 赵越.香叶木苷的抗辐射损伤作用机制研究[D].黑龙江:哈尔滨工业大学,2013. -
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