Abstract: Core- shell magnetic polymers( MGTP Ⅰ) were prepared by using acrylic acid( AA) as functional monomer,ethyleneglycol dimethacrylate( EGDMA) as cross- linking agent,and hydroxy- modified MGT nanoparticles as the magnetic core. Morphology,structure,magnetic properties,thermal stability of MGTPⅠ were characterized by scanning electron microscopy( SEM),fourier transform infrared spectroscopy( FTIR),vibrating sample strong magnetic analysis( VSM),thermogravimetric analysis( TGA). Re- binding experiments were undertaken for the study of the adsorption thermodynamic and kinetic,which could make sure adsorption model of the materials.The results showed that the MGTPⅠ had a fast adsorption equilibrium( adsorption equilibrium time was just 60 min) and nice adsorption capacity( the max adsorption was 89.53 mg / g). The MGTP Ⅰ could be applied to the enrichment and determination of tolbutamide in hypoglycemic health products with the recoveries of spiked hypoglycemic granule,hypoglycemic tablets,and hypoglycemic tea ranging from 88.91% to 95.20%,81.63% to 107.49%,and 92.10% to 102.99%,respectively,and the RSD was ≤2.53%,the limit of detection( LOD) was0.15 μg / m L. The durability test showed that the MGTP Ⅰ could be reused more than 4 times by re- binding experiments.By using an external magnetic field,the absorbed analytes were efficiently separated,so it was a promising method to conveniently detect the illegal addition of tolbutamide in hypoglycemic health products.