Kinetic models for uridine 5'- monophosphate batch fermentation by Saccharomyces cerevisiae
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摘要: 对酿酒酵母工程菌产UMP的分批发酵动力学进行了研究。通过对Logistic方程、Leudeking-Piret方程和类Luedeking-Piret方程进行参数估计和非线性数据拟合,分别得到发酵过程中菌体干重、UMP产量、残糖含量动力学模型及模型参数。对拟合曲线进行分析,结果表明模型值与实验值拟合性良好,线性拟合度大于98%,所建立模型能较好的反映UMP的分批发酵过程。Abstract: The dynamic models for uridine 5'- monophosphate batch fermentation by Saccharomyces cerevisiae recombinant strain was studied. The kinetic models for dry cell weight,the content of uridine 5'- monophosphate and residual sugar were proposed with the Logistic equation,Leudeking- Piret equation and class Luedeking- Piret equation though the parameters estimation and nonlinear least- squares fitting method.The results showed that the experimental values and the fitted values fit well by analyze fitted curve,the fit of the linear over 98%.The models can reflect the batch fermentation of uridine 5'- monophosphate well.
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Keywords:
- uridine 5'-monophosphate; /
- linear fit /
- kinetics
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1. 韦艳萍,谭栀恩,陀海燕,曾佩琴,刘雅婷,覃柳馨,易蔚,陈卫卫. 星点设计-效应面法优选小儿益肺健脾煎膏剂提取工艺研究. 中国医药导报. 2021(01): 13-17+35+197 . 百度学术
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