Abstract: Reverse high performance liquid chromatography method was developed for the determination of NVP in PVPP. The Sample were extracted by water and analyzed by using UV detector at 235 nm. The liquid phase was acetonitrile/water(10∶90). The experimental results showed that the linear range of NVP was 0.025~1.0μg/m L,Correlative coefficient was 0.9999. The limit of quantitation was 1.0mg/kg,the average recoveries were 96.0%~103.0%,the coefficient of variation were 1.06%~2.64%. This method showed simple,good separation effect and high recoveries and precision met the demand of analysis.