Abstract: The effect of adsorption debittering on phenolic compounds of Guanxi pomelo juice were studied. A HPLC method had been developed to determinate concentration changes in phenolic compounds of the pomelo juice after the Amberlite XAD-16 resin adsorption. The result showed that the pomelo juice contained six phenolic compounds, namely chlorogenic acid, caffeine acid, p-coumaric, ferulic acid, ruin, naringin. The HPLC method had recoveries to these phenolic compounds in a range within 85.0% to 103.6%, and the relative standard deviations was in a range within 0.48%².9%. After resin adsorption debittering treatment, p-coumaric, ferulic acid, ruin could not be detected, and the content of chlorogenic acid, naringin, caffeine acid decreased 97.2%, 93.5%, 87.9% of pomelo juice, respectively. These results indicate that the resin adsorption debittering dramatically reduce the content of chlorogenic acid, caffeine acid, p-coumaric, ferulic acid, ruin, naringin in the pomelo juice.