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中国精品科技期刊2020

1,8-桉叶油素对小鼠的经口急性毒性和蓄积毒性的研究

杜永华, 王川, 周黎军, 张萍, 魏琴, 殷中琼, 蒋勤久, 蒋吉洪

杜永华, 王川, 周黎军, 张萍, 魏琴, 殷中琼, 蒋勤久, 蒋吉洪. 1,8-桉叶油素对小鼠的经口急性毒性和蓄积毒性的研究[J]. 食品工业科技, 2013, (21): 335-337. DOI: 10.13386/j.issn1002-0306.2013.21.017
引用本文: 杜永华, 王川, 周黎军, 张萍, 魏琴, 殷中琼, 蒋勤久, 蒋吉洪. 1,8-桉叶油素对小鼠的经口急性毒性和蓄积毒性的研究[J]. 食品工业科技, 2013, (21): 335-337. DOI: 10.13386/j.issn1002-0306.2013.21.017
DU Yong-hua, WANG Chuan, ZHOU Li-jun, ZHANG Ping, WEI Qin, YIN Zhong-qiong, JIANG Qin-jiu, JIANG Ji-hong. The oral acute and accumulative toxicity of 1, 8-cineole on mice[J]. Science and Technology of Food Industry, 2013, (21): 335-337. DOI: 10.13386/j.issn1002-0306.2013.21.017
Citation: DU Yong-hua, WANG Chuan, ZHOU Li-jun, ZHANG Ping, WEI Qin, YIN Zhong-qiong, JIANG Qin-jiu, JIANG Ji-hong. The oral acute and accumulative toxicity of 1, 8-cineole on mice[J]. Science and Technology of Food Industry, 2013, (21): 335-337. DOI: 10.13386/j.issn1002-0306.2013.21.017

1,8-桉叶油素对小鼠的经口急性毒性和蓄积毒性的研究

基金项目: 

四川省青年科技创新研究团队培育计划(2011JTD0035); 四川省教育厅成果转化培育项目(11ZZ022);

详细信息
    作者简介:

    杜永华 (1978-) , 男, 硕士, 讲师, 主要从事天然产物及其生物活性的研究。;

  • 中图分类号: R114

The oral acute and accumulative toxicity of 1, 8-cineole on mice

  • 摘要: 采用改良寇氏法测试了1,8-桉叶油素对小鼠的急性毒性,并采用固定剂量蓄积毒性系数法测试了其蓄积毒性。结果表明,1,8-桉叶油素对小鼠经口半数致死剂量(LD50)为3847.34mg/kg.bw,95%置信限为3352.804414.82mg/kg.bw,急性中毒主要靶器官为肝脏和肾脏;小鼠蓄积性毒性实验所得蓄积系数K>5,与对照组相比,1,8-桉叶油素对小鼠饲料利用率与脏器系数无明显影响(p>0.05),对脏器无明显不良影响。可见1,8-桉叶油素对小鼠属于低毒化学物质,无明显蓄积毒性。 
    Abstract: The oral acute toxicity of 1, 8- cineole on mice was tested by the modified Karber method, and the oral accumulative toxicity was carried out by a fixed dose method.The results showed that the half-lethal dose ( LD50) of1, 8-cineole was 3847.34 mg /kg.bw with the 95% confidence interval of 3352.80 ~ 4414.82mg /kg.bw. The liver and kidney were the key targets organ of acute poisoning of 1, 8- cineole on mice. The accumulative toxicity test revealed that the accumulative coefficient K was larger than 5.No obviously influence of 1, 8- cineole on the feed conversion rate and organ coefficient of mice was observed compared to the control group ( p > 0.05) .1, 8-cineole exhibited no obviously harmful effects on organ of mice.1, 8-cineole displayed low acute toxicity and no obviously accumulative toxicity.
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出版历程
  • 收稿日期:  2013-04-16

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