杀铃脲缓释微胶囊制备表征及缓释性能的研究

宇佳; 关桦楠; 田可; 李晓灿; 严俊鑫; 迟德富

doi:10.13386/j.issn1002-0306.2013.19.016

杀铃脲缓释微胶囊制备表征及缓释性能的研究

1. 东北林业大学林学院
2. 哈尔滨商业大学食品工程学院
3. 东北林业大学园林学院

基金项目:

国家科技支撑计划课题(2012BAD19B07)；

详细信息

作者简介:
宇佳 (1978-) , 女, 助理研究员, 主要从事农药微胶囊研究。;

中图分类号: R114
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出版历程
- 收稿日期: 2013-03-05

Triflumuron microcapsules: preparation, characterization and control released properties

School of Forestry, Northeast Forestry University
College of Food Engineering, Harbin University of Commerce
College of Landscape, Northeast Forestry University

摘要

摘要: 为了提高农药在生态环境中的持效性和生物安全性,采用层层自组装技术,构建了杀铃脲微胶囊,并对其性能进行表征。结果表明:利用正交实验确定杀铃脲微胶囊制备的最优工艺条件为:3.0g/L海藻酸钠,2.0g/L壳聚糖,1.0g/L杀铃脲和2.0g/L CaCl2,其中,壳聚糖的浓度对包埋微胶囊效果影响最大,所得杀铃脲微胶囊的包封率和载药量分别为77.4%和75.2%;通过激光共聚焦显微镜（CLSM）与扫描电镜（SEM）对杀铃脲微胶囊进行表征,晶体形状良好,表面光滑,没有药物溶出,平均粒径为6μm,Zeta电位为-12.5mV,通过体外缓释实验的研究证实随着包覆层数的增加,杀铃脲微胶囊的缓释性能明显增强。
- 农药 /
- 杀铃脲 /
- 微胶囊 /
- 缓释性能
Abstract: In order to improve pesticide biological security and sustained effect in the ecological environment, the triflumuron (TFM) was directly encapsulated through layer-by-layer (LbL) self-assembly method.The results showed that the optimum conditions screened by orthogonal experiments for preparing TFM microencapsulation were 3.0g /L sodium alginate, 2.0g /L nature chitosan, 1.0g /L TFM and 2.0g /L CaCl 2.The effect of chitosan concentration was most significant among those4elements evaluated in the orthogonal experiment.The encapsulation efficiency and drug loading of the microcapsule prepared with optimum conditions were 77.4% and 75.2% respectively.The coated colloids were characterized using confocal laser scanning microscopy (CLSM) and scanning electron microscopy (SEM) .For the TFM microcapsules prepared with the optimized system, the surface was smooth and there is no drug dissolution, the mean grain size was6μm, their Zeta potential was-12.5mV.The in vitro release experiment revealed that the controlled-release property of TFM microcapsules, prepared by this method, significantly enhanced with the increasing of the cladding layers.
- triflumuron /
- microcapsules /
- orthogonal design /
- sustained release

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