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中国精品科技期刊2020

食品源性降血压活性肽的研究进展

沈亮

沈亮. 食品源性降血压活性肽的研究进展[J]. 食品工业科技, 2013, (14): 390-394. DOI: 10.13386/j.issn1002-0306.2013.14.024
引用本文: 沈亮. 食品源性降血压活性肽的研究进展[J]. 食品工业科技, 2013, (14): 390-394. DOI: 10.13386/j.issn1002-0306.2013.14.024
Research progress in food protein-derived antihypertensive peptides[J]. Science and Technology of Food Industry, 2013, (14): 390-394. DOI: 10.13386/j.issn1002-0306.2013.14.024
Citation: Research progress in food protein-derived antihypertensive peptides[J]. Science and Technology of Food Industry, 2013, (14): 390-394. DOI: 10.13386/j.issn1002-0306.2013.14.024

食品源性降血压活性肽的研究进展

基金项目: 

山东省星火计划(2011XH13005); 山东省科技攻关计划项目(2011YD10008); 德州市科技发展计划项目(2011B04);

详细信息
  • 中图分类号: R151

Research progress in food protein-derived antihypertensive peptides

  • 摘要: 食源性生物活性肽具有提升人体的健康状况以及治疗多种疾病的功能,尤其是调节血压的能力已经得到了证实。研究表明这些多肽的药理作用和其本身的结构相关,还取决于目标组织对它们的吸收和利用的效率。文章总结了一些重要的抗高血压多肽和功能性食品的降压效果,降压的分子机制,影响因素,多肽的制备分离等内容。结果表明,未来的研究将集中在生物活性肽在受试患者体内降血压作用的评价、生物利用度和药代谢动力学方面。 
    Abstract: Bioactive peptides (BAPs) , derived through enzymatic hydrolysis of food proteins, have demonstrated potential for application as health-promoting agents against numerous human health and disease conditions, especially regulation of blood pressure (BP) .The feasibility of pharmacological application of these peptides depends on absorption and bioavailability in intact forms in target tissues, which in turn depends on structure of the peptides.In this article, the literature on antihypertensive peptides and functional food were reviewed, with emphasis on BP-lowering activity, molecular mechanisms of BP-lowering, influencing factors, and the methods of production and purification, etc.The future research efforts on BAPs should be directed toward evaluation of health-promoting effects in vivo, bioavailability and pharmacokinetics inhuman subjects.
  • [1]

    Hernández-Ledesma B, Hsieh C-C, de Lumen BO.Lunasin, a novel seed peptide for cancer prevention[J].Peptides, 2009, 30:426-430.

    [2]

    Korhonen H, Pihlanto A.Bioactive peptides:production and functionality[J].Int Dairy J, 2006, 16:945-960.

    [3]

    Fitzgerald C, Gallagher E, Tasdemir D, et al.Heart health peptides from macroalgae and their potential use in functional foods[J].J Agric Food Chem, 2011, 59:6829-6836.

    [4]

    Pripp AH, Isaksson T, Stepaniak L, et al.Quantitative structure-activity relationship modelling peptides and proteins as a tool in food science[J].Trends Food Sci Technol, 2005, 16:484-494.

    [5]

    Ibrahim MM.RAS inhibition in hypertension[J].J Hum Hypertens, 2006, 20:101-108.

    [6]

    Segall L, Covic A, Goldsmith DJA.Direct renin inhibitors:the dawn of a new era, or just a variation on a theme[J].Nephrol Dial Transplant, 2007, 22:2435-2439.

    [7]

    Ferreira SH, Bartelt DC, Greene LJ.Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom[J].Biochemistry, 1970, 9:2583-2593.

    [8]

    Ondetti MA, Williams NJ, Sabo EF, et al.Angiotensinconverting enzyme inhibitors from the venom of Bothrops jararaca:isolation, elucidation of structure and synthesis[J].Biochemistry, 1971, 10:4033-4039.

    [9]

    FitzGerald RJ, Murray BA, Walsh DJ.Hypotensive peptides from milk proteins[J].J Nutr, 2004, 134:980-988.

    [10]

    Aluko RE.Determination of nutritional and bioactive properties of peptides in enzymatic pea, chickpea, and mung bean protein hydrolysates[J].J AOAC Int, 2008, 91:947-956.

    [11]

    Aluko RE.Antihypertensive properties of plant-derived inhibitors of angiotensin Iconverting enzyme activity[J].Recent Progress in Medicinal Plants-Phytopharmacology and Therapeutic, 2008, 22 (4) :541-561.

    [12]

    Aluko RE.Technology for the production and utilization of food protein-derived antihypertensive peptides:A review[J].Recent Pat Biotechnol, 2007, 1:260-267.

    [13]

    Nakamura Y, Yamamoto N, Sakai K, et al.Purification and characterization of angiotensin I-converting enzyme inhibitors from a sour milk[J].J Dairy Sci, 1995, 78:777-783.

    [14]

    Sato M, Hosokawa T, Yamaguchi T, et al.Angiotensin I-converting enzyme inhibitory peptides derived fr om wakame (Undaria pinnatifida) and their antihypertensive effect in spontaneously hypertensive rats[J].J Agric Food Chem, 2002, 50:6245-6252.

    [15]

    Wu J, Aluko RE, Nakai S.Structural requirements of angiotensin I-converting enzyme inhibitory peptides:quantitative structure-activity relationship study of di-and tripeptides[J].J Agric Food Chem, 2006, 54:732-738.

    [16]

    Wu J, Aluko RE, Nakai S.Structural requirements of angiotensin I-converting enzyme inhibitory peptides:quantitative structure-activity relationship modelling of peptides containing4-10amino acid residues[J].QSAR Comb Sci, 2006, 25:873-880.

    [17]

    Vermeirssen V, Van Camp J, Verstraete W.Bioavailability of angiotensin I converting enzyme inhibitory peptides[J].Brit J Nutr, 2004, 92:357-366.

    [18]

    Udenigwe CC, Lin Y-S, Hou W-C, et al.Kinetics of the inhibition of renin and angiotensin I-converting enzyme by flaxseed protein hydrolysate fractions[J].J Funct Foods, 2009 (1) :199-207.

    [19]

    Girgih AT, Udenigwe CC, Li H, et al.Kinetics of enzyme inhibition and antihypertensive effects of hemp seed (Cannabis sativa L.) protein hydrolysates[J].J Am Oil Chem Assoc, 2011, 88 (11) :1767-1774.

    [20]

    Li H, Aluko RE.Identification and inhibitory properties of multifunctional peptides from pea protein hydrolysate[J].J Agric Food Chem, 2010, 58∶11471-11476.

    [21]

    Udenigwe CC, Li H, Aluko RE.Quantitative structure-activity relationship modelling of renin-inhibiting dipeptides[J].Amino Acids, 2012, 42 (4) :1379-1386.

    [22]

    Hata Y, Yamamoto M, Ohni M, et al.A placebocontrolled study of the effect of sour milk on blood pressure in hypertensive subjects[J].Am J Clin Nutr, 1996, 64:767-771.

    [23]

    Boelsma E, Kloek J.IPP-rich milk protein hydrolysate lowers blood pressure in subjects with stage1hypertension, a randomized controlled trial[J].Nutr J, 2010 (9) :52.

    [24] Pins JJ, Keenan JM.The antihypertensive effects of a hydrolysed whey protein isolate supplement (BioZate誖1) [J].Cardiovas Drugs Ther, 2002, 16 (1) :68.
    [25]

    Van Mierlo LAJ, Koning MMG, Van Zander KD, et al.Lactotripeptides do not lower ambulatory blood pressure in untreated whites:results from2controlled multicenter crossover studies[J].Am J Clin Nutr, 2009, 89:617-623.

    [26]

    Usinger L, Jensen LT, Flambard B, et al.The antihypertensive effect of fermented milk in individuals with prehypertension or borderline hypertension[J].J Hum Hypertens, 2010, 24:678-683.

    [27]

    Sipola M, Finckenberg P, Santisteban J, et al.Longterm intake of milk peptides attenuates development of hypertension in spontaneously hypertensive rats[J].J Physiol Pharmacol, 2001, 52:745-754.

    [28] Ruiz-Giménez P, Ibá觡ez A, Salom JB, et al.Antihypertensive properties of lactoferricin B-derived peptides[J].J Agric Food Chem, 2010, 58:6721-6727.
    [29]

    Kawasaki T, Seki E, Osajima K, et al.Antihypertensive effect of valyl-tyrosine, a short chain peptide derived from sardine muscle hydrolyzate, on mild hypertensive subjects[J].J Hum Hypertens, 2000, 14:519-523.

    [30]

    Barba de la Rosa AP, Barba Montoya A, Martinez-Cuevas, et al.Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE:Antihypertensive role of amaranth peptides[J].Nitric Oxide, 2010, 23:106-111.

    [31]

    Pripp AH.Effect of peptides derived from food proteins on blood pressure:a meta-analysis of randomized controlled trials[J].Food Nutr Res, 2008, 52:1-9.

    [32]

    Xu J-Y, Qin L-Q, Wang P-Y, et al.Effect of milk tripeptides on blood pressure:a meta-analysis of randomized controlled trials[J].Nutrition, 2008, 24:933-940.

    [33]

    Cicero AFG, Gerocarni B, Laghi L, et al.Blood pressure lowering effect of lactotripeptides assumed as functional foods:a meta-analysis of current available clinical trials[J].J Hum Hypertens, 2011, 25:425-436.

    [34]

    Wang W, Gonzalez de Mejia E.A new frontier in soy bioactive peptides that may prevent age-related chronic diseases[J].Compr Rev Food Sci Food Safety, 2005 (4) :63-78.

    [35]

    Phelan M, Ahernea A, FitzGerald RJ, et al.Casein-derived bioactive peptides:biological effects, industrial uses, safety aspects and regulatory status[J].Int Dairy J, 2009, 19:643-654.

    [36]

    Alemán A, Pérez-Santín E, Bordenave-Juchereau S, et al.Squid gelatin hydrolysates with antihypertensive, anticancer and antioxidant activity[J].Food Res Int, 2011, 44:1044-1051.

    [37]

    Germino FW, Neutel J, Nonaka M, et al.The impact of lactotripeptides on blood pressure response in stage1and stage2hypertensives[J].J Clin Hypertens, 2010, 12:153-159.

    [38]

    Udenigwe CC, Aluko RE.Antioxidant and angiotensin converting enzyme-inhibitory properties of a flaxseed protein-derived high Fischer ratio peptide mixture[J].J Agric Food Chem, 2010, 58:4762-4768.

    [39]

    Pownall TL, Udenigwe CC, Aluko RE.Amino acid composition and antioxidant properties of pea seed (Pisum sativum L.) enzymatic protein hydrolysate fractions[J].J Agric Food Chem, 2010, 58:4712-4718.

    [40]

    Pownall TL, Udenigwe CC, Aluko RE.Effects of cationic property on the in vitro antioxidant activities of pea protein hydrolysate fractions[J].Food Res Int, 2011, 44:1069-1074.

    [41]

    Doyen A, Beaulieu L, Saucier L.Demonstration of in vitro anticancer properties of peptide fractions from a snow crab by-products hydrolysate after separation by electrodialysis with ultrafiltration membranes[J].Sep Purif Technol, 2011, 78:321-329.

    [42]

    Kasika V.Recent developments in CE and CEC of peptides (2009-2011) [J].Electrophoresis, 2012, 33:48-73.

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  • 收稿日期:  2013-02-18

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