Abstract: The objective of this study was to explore the in vitro antioxidant activities and the active compounds contents of different solvent extracts from Vaccinium blueberry leaves. The Vaccinium blueberry leaves were extracted with distilled water, methanol, ethanol, ethyl acetate, chloroform and petroleum ether, respectively. The contents of total phenolics and flavonoids in different extracts were detected by the Folin-Ciocalie method and the aluminium trichloride colorimetry method. Meanwhile, the antioxidant activity and the anti-lipid peroxidation activity of extracts from blueberry leaves were investigated by 1 , 1-diphenyl-2- picrylhydrazyl (DPPH) free radical scavenging assay, 2, 2′-Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) free radical scavenging assay and β-carotene/linoleic acid system. Furthermore, the correlation between the contents of the active compounds and antioxidant properties was analyzed. The data showed that the antioxidant activity of extracts from blueberry leaves decreased with the reducing of polarity of extracted solvents. The water extract showed remarkable scavenging activity on DPPH· EC 50 (12.78±0.10) , ABTS + · EC 50 (6.35±0.03) μg/mL, and prominent β-carotene bleaching effect IC 50 (25.33±0.02) μg/mL. The water extract had the highest total phenolics content (264.67±0.29) mg/g and methanol extract had the highest flavonoids content (68.94 ±0.08) mg/g among different solvent extracts. Analyses indicated that different solvent extracts from blueberry leaves showed a significant difference in their antioxidant activities, and a correlation between their contents of the active compounds and antioxidant properties. It was revealed that water could be one of the best solvents used for extract antioxidant ingredients from blueberry leaves, and the contents of total phenolics and flavonoids could be the quality evaluation index of antioxidant extracts from blueberry leaves.