芹菜素对癌细胞作用机理的研究进展
详细信息Research progress in mechanism of apigenin’s anticarcinogenic activity on cancer cells
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摘要: 芹菜素是芹菜中含有的一种重要的黄酮类物质,对多种癌细胞都有抑制其生长和促使其凋亡的作用,但是它对于癌细胞产生作用的具体机制尚未得到全面准确的阐释。本文参考近年来对芹菜素抗癌作用的研究的相关文献,分别对芹菜素对一些癌细胞的作用机制做了归纳和探讨。芹菜素对癌细胞作用的机理研究已经深入到细胞和分子水平,抑癌机理包括对基因和蛋白的抑制或激活,对信号因子的调节,干预酶发挥作用等。对芹菜素的抗癌作用机理的研究是通过饮食对癌症进行化学预防的一个重要部分,芹菜素作为癌症化学预防制剂具有广阔的应用前景。Abstract: Apigenin is an important flavonoid in Apium graveolens. It has the effect of inhibition and cell apotosis induction on many kinds of cancer cells.But the mechanism of its effect on cancer cells has not yet been explained thoroughly and accurately.In this paper, apigenin’s anti- cancer effect was summarized and discussed with the reference of relevant literatures of anticarcinogenic activity in recent years. The research of the mechanism was further concentrated on the cellular and molecular levels including the inhibition or activation on gene and protein, regulation of signal factor, intervention of enzyme activity. This research of the mechanism of apigenin ’s anticarcinogenic activity was an important part of cancer chemoprevention, which provided theory basis for its application as a cancer chemoprevention agent.
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Keywords:
- apigenin;cancer cells;inhibition;mechanism; /
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