加工肉制品中杂环胺的检测方法及抑制措施的研究进展
详细信息Research progress in detection methods and control measures for heterocyclic aromatic amines in processed meat products
-
摘要: 杂环胺是肉类等高蛋白食品在烹调过程中产生一类具有致癌、致突变作用的化合物。目前已经从高温肉制品中发现近三十种的杂环胺。美国国家毒理学计划在第十一届癌症报告中将五种杂环胺列入潜在的人类致癌物质,且国际癌症研究中心也将三种杂环胺列入潜在的人类致癌物质。鉴于杂环胺可能对人类的健康带来极大危害,本文结合过去多年的文献研究,介绍了杂环胺的提取及检测方法,并对肉制品中杂环胺的抑制措施进行了概述,以期为将来研究提供科学参考。Abstract: Heterocyclic aromatic amines are mutagenic and carcinogenic compounds that are formed naturally during cooking of proteinaceous foods such as meat. There are about 30 kinds of heterocyclic aromatic amines have been found at present.Five kinds of heterocyclic aromatic amines have been listed as potential carcinogens in the eleventh US National Toxicology Program Report on carcinogens, while three kinds of heterocyclic aromatic amines have also been affirmed as potential carcinogens by the International Agency for Research on Cancer ( IARC) .Meat pretreatment and detection methods for heterocyclic aromatic amines were introduced, while control measures were summarized.
-
[1] Felton J S, Fultz E, Dolbeare F A, et al.Reduction of heterocyclic aromatic amine mutagens/carcinogens in fried beef patties by microwave[J].Food Chem Toxicol, 1994, 32 (10) :897-903.
[2] Sugimura T, Nagao M, Kawachi T, et al.Mutagen-carcinogens in food, with special reference to highly mutagenic pyrolytic products in broiled foods[M].New York:Cold Spring Harbor, 1977:1561-1577.
[3] Wakabayashi K, Totsuka Y, Fukutome K, et al.Human exposure to mutagenic/carcinogenic heterocyclic amines and comutagenic beta-carbolines[J].Mutat Res, 1997, 376 (1-2) :253-259.
[4] Gross G A, Gruter A.Quantitation of mutagenic/carcinogenic heterocyclic aromatic amines in food products[J].J Chromatogr A, 1992, 592 (1-2) :271-278.
[5] Thiebaud H P, Knize M G, Kuzmicky P A, et al.Mutagenicity and chemical analysis of fumes from cooking meat[J].J Agric Food Chem, 1994, 42 (7) :1502-1510.
[6] Smith C J, Qian X L, Zha Q M, et al.Analysis ofα-andβ-carbolines in mainstream smoke of reference cigarettes by gas chromatography-mass spectrometry[J].J Chromatogr A, 2004, 1046 (1-2) :211-216.
[7] Messner C, Murkovic M.Evaluation of a new model system for studying the formation of heterocyclic amines[J].J Chromatogr B, 2004, 802 (1) :19-26.
[8] Gu Y S, Kim I S, Ahn J K, et al.Mutagenic and carcinogenic heterocyclic amines as affected by muscle types/skin and cooking in pan-roasted mackerel[J].Mutat Res, 2002, 515 (1-2) :189-195.
[9] Alaejos M S, Ayala J H, González V, et al.Analytical methods applied to the determination of heterocyclic aromatic amines infoods[J].J Chromatogr B, 2008, 862 (1-2) :15-42.
[10] Kataoka H, Kijima K.Analysis of heterocyclic amines as their N-dimethylaminomethylene derivatives by gas chromatography with nitrogen-phosphorus selective detection[J].J Chromatogr A, 1997, 767 (1-2) :187-194.
[11] Skog K, Solyakov A, Arvidsson P, et al.Analysis of nonpolar heterocyclic amines in cooked foods and meat extracts using gas chromatography-mass spectrometry[J].J Chromatogr A, 1998, 803 (1-2) :227-233.
[12] Warzecha L, Janoszka B, Blazczyk U, et al.Determination of heterocyclic aromatic amines (HAs) content in samples of household-prepared meat dishes[J].J Chromatogr B, 2004, 802 (1) :95-106.
[13] Casal S, Mendes E, Fernandes J O, et al.Analysis of heterocyclic aromatic amines in foods by gas chromatography-mass spectrometry as their tert-butyldimethylsilyl derivatives[J].J Chromatogr A, 2004, 1040 (1) :105-114.
[14] Sasaki T A, Wilkins J M, Forehand J B, et al.Analysis of heterocyclic amines in mainstream cigarette smoke nci GC-MS technique[J].Anal Lett, 2001, 34 (10) :1749-1761.
[15] Oz F, Kaban G, Kaya M.Effects of cooking methods on the formation of heterocyclic aromatic amines of two different species trout[J].Food Chem, 2007, 104 (1) :67-72.
[16] Warzecha L, Janoszka B, Blaszczyk U, et al.Determination of heterocyclic aromatic amines (HAs) content in samples of household-prepared meat dishes[J].J Chromatogr B, 2004, 802 (1) :95-106.
[17] Puangdombat K, Gadgil P, Houser T A, et al.Heterocyclic amine content in commercial ready to eat meat products[J].Meat Sci, 2011, 88 (2) :227-233.
[18] Pais P, Salmon C P, Knize M G, et al.Formation of mutagenic/carcinogenic heterocyclic amines in dry-heated model systems, meats, and meat drippings[J].J Agric Food Chem, 1999, 47 (3) :1098-1108.
[19] Cheng K W, Wu Q, Zheng Z P, et al.Inhibitory effect of fruit extracts on the formation of heterocyclic amines[J].J Agric Food Chem, 2007, 55 (25) :10359-10365.
[20] 吕美, 曾茂茂, 陈洁.烹调肉制品中杂环胺的检测技术和控制手段研究进展[J].食品科学, 2011, 32 (13) :345-349. [21] Lee J, Dong A, Jung K, et al.Influence of extra virgin olive oil on the formation of heterocyclic amines in roasted beef steak[J].Food Sci Biotechnol, 2011, 20 (1) :159-165.
[22] 吕美.香辛料的抗氧化性及其对煎烤牛肉饼中杂环胺形成的影响[D].无锡:江南大学, 2011. [23] Barceló-Barrachina E, Moyano E, Galceran M T, et al.Ultra-performance liquid chromatography-tandem mass spectrometry for the analysis of heterocyclic amines in food[J].J Chromatogr A, 2006, 1125 (2) :195-203.
[24] Oz F, Kaban G, Kaya M.Effects of cooking methods and levels on formation of heterocyclic aromatic amines in chicken and fish with Oasis extraction method[J].LWT-Food Sci Technol, 2010, 43 (9) :1345-1350.
[25] Liao G Z, Wang G Y, Xu X L, et al.Effect of cookingmethods on the formation of heterocyclic aromatic amines in chicken and duck breast[J].Meat Sci, 2010, 85 (1) :149-154.
[26] Sinha R, Rothman N, Salmon C P, et al.Heterocyclic amine content in beef cooked by different methods to varying degrees of doneness and gravy made from meat drippings[J].Food Chem Toxicol, 1998, 36 (4) :279-287.
[27] Skog K, Solyakov A, Jǎgerstad, et al.Effects of heating conditions and additives on the formation of heterocyclic amines with reference to amino-carbolines in a meat juice model system[J].Food Chem, 2000, 68 (3) :299-308.
[28] Bordas M, Moyano E, Puignou L, et al.Formation and stability of heterocyclic amines in a meat flavor model system.Effect of temperature, time and precursors[J].J Chromatogr B, 2004, 802 (1) :11-17.
[29] Abdulkarim B G, Smith J S.Heterocyclic amines in fresh and processed meat products[J].J Agric Food Chem, 1998, 46 (11) :4680-4687.
[30] Arvidsson P, van Boekel M A J S, Skog K, et al.Formation of heterocyclic amines in a meat juice model system[J].J Food Sci, 1999, 64 (2) :216-221.
[31] Damaius J, Venskutonis P R, Ferracane R, et al.Assessment of the influence of some spice extracts on the formation of heterocyclic amines in meat[J].Food Chem, 2011, 126 (1) :149-156.
[32] Balogh Z, Gray J I, Gomma E A, et al.Formation and inhibition of heterocyclic aromatic amines in fried ground beef patties[J].Food Chem Toxicol, 2000, 38 (5) :395-401.
[33] Persson E, Graziani G, Ferracane R, et al.Influence of antioxidants in virgin olive oil on the formation of heterocyclic amines in fried beefburgers[J].Food Chem Toxicol, 2003, 41 (11) :1587-1597.
[34] Oz F, Kaya M.The inhibitory effect of black pepper on formation of heterocyclic aromatic amines in high-fat meatball[J].Food Control, 2011, 22 (3-4) :596-600.
[35] Puangsombat K, Jirapakkul W, Smith J S.Inhibitory activityof asian spices on heterocyclic amines formation in cooked beef patties[J].J Food Sci, 2011, 76 (8) :174-180.
[36] Wong D, Cheng K W, Wang M.Inhibition of heterocyclic amine formation by water-soluble vitamins in Maillard reaction model systems and beef patties[J].Food Chem, 2012, 133 (3) :760-766.
[37] Cheng K W, Zeng X, Tang Y S, et al.Inhibitory mechanism of naringenin against carcinogenic acrylamide formation and non-enzymatic browning in Maillard model reactions[J].Chem Res Toxicol, 2009, 22 (8) :1483-1489.
[38] Cheng K W, Wong C C, Chao J, et al.Inhibition of mutagenic PhIP formation by EGCG via scavenging of phenylacetaldehyde[J].Mol Nutr Food Res, 2009, 53 (6) :716-725.
[39] Cheng K W, Chen F, Wang M.Inhibitory activities of dietary phenolic compounds on heterocyclic amine formation in both chemical model systems and beef patties[J].Mol Nutr Food Res, 2007, 51 (8) :969-976.
[40] Lan C M, Kao T H, Chen B H.Effects of heating time and antioxidants on the formation of heterocyclic amines in marinated foods[J].J Chromatogr B, 2004, 802 (1) :27-37.
[41] Gibis M, Effect of oil marinades with garlic, onion, and lemon juice on the formation of heterocyclic aromatic amines in fried beef patties[J].J Agric Food Chem, 2007, 55 (25) :10240-10247.
[42] Quelhas I, Petisca C, Viegas O, et al.Effect of green tea marinades on the formation of heterocyclic aromatic amines and sensory quality of pan-fried beef[J].Food Chem, 2010, 122 (1) :98-104
[43] Ahn J, Grǔn I U.Heterocyclic amines:2.inhibitory effects of natural extracts on the formation of polar and nonpolar heterocyclic amines in cooked beef[J].J Food Sci, 2005, 70 (4) :263-268.
[44] Stavric B, Matula T I, Klassen R, et al.The effect of teas on the in vitro mutagenic potential of heterocyclic aromatic amines[J].Food Chem Toxicol, 1996, 34 (6) :515-523.
-
期刊类型引用(6)
1. 蔡文强,崔嘉航,朱慧慧,刘瑞,李楠,孙元琳. 不同提取方法红芸豆皮膳食纤维结构、理化性质和降血糖活性分析. 食品与发酵工业. 2025(01): 237-243 . 百度学术
2. 西尔艾力·马拉江,祖力克艳·麻那甫,特列克·阿依恒别克,赛福丁·阿不拉,阿得力江·吾斯曼. 响应面法优化骆驼刺多糖的提取工艺. 新疆畜牧业. 2024(05): 20-25 . 百度学术
3. 张瑞麟,曹漫钰,杜超,刘佳慈,臧延青. 响应面法优化英国红芸豆多糖提取工艺及抗氧化活性研究. 黑龙江八一农垦大学学报. 2023(06): 68-73+110 . 百度学术
4. 朱新术,赵文慧,张晓蕾,林波,刘超,张苗,陈菲. 木聚糖酶重组毕赤酵母合成培养基的Plackett-Burman法优化. 食品工业科技. 2020(07): 109-114 . 本站查看
5. 刘玉秀,刘苗苗,张正茂. 黑小麦品种选育与营养加工研究. 麦类作物学报. 2020(06): 698-706 . 百度学术
6. 吴莹晗,马丹妮,李华. 黑小麦营养价值 功能性物质及其影响因素的研究进展. 农产品加工. 2019(18): 58-60 . 百度学术
其他类型引用(3)
计量
- 文章访问数: 110
- HTML全文浏览量: 12
- PDF下载量: 974
- 被引次数: 9