白背三七对小鼠胃肠蠕动功能的影响
详细信息Effect of gynura divaricata on the function of gastrointestinal motility in mice
-
摘要: 目的:观察白背三七对小鼠胃肠蠕动功能的影响。方法:在体观察白背三七对正常小鼠和阿托品致便秘模型小鼠胃排空率和小肠碳末推进率的影响;离体观察白背三七对正常离体小肠和阿托品抑制离体小肠收缩频率和收缩张力的影响。结果:白背三七能提高正常小鼠胃排空率和小肠碳末推进率,与正常对照组比较具有显著性差异(p<0.01或p<0.05);能提高阿托品致便秘小鼠胃排空率和小肠碳末推进率,与阿托品组比较具有显著性差异(p<0.01或p<0.05);能提高正常小鼠离体小肠收缩频率和收缩张力,与正常对照组比较具有显著性差异(p<0.01或p<0.05);能提高阿托品抑制离体小肠收缩频率和收缩张力,与阿托品组比较具有显著性差异(p<0.01或p<0.05)。结论:白背三七能增强小鼠胃肠蠕动功能。Abstract: Objective:To observe the effect of gynura divaricata on the function of gastrointestinal motility in mice.Methods:Effect of gynura divaricata on the rate of gastric emptying and small intestine facilitation in normal mice and constipation mice induced by atropine in vivo were observed, and contraction frequency and contraction tension in normal small intestine and inhibition small intestine by atropine in vitro were also observed.Result:Gynura divaricata could elevate the rate of gastric emptying and small intestine facilitation in normal mice comparing with normal mice ( p < 0.01 or p < 0.05) , gynura divaricata could also elevate the rate of gastric emptying and small intestine facilitation in constipation mice induced by atropine comparing with model mice ( p < 0.01 or p < 0.05) . Gynura divaricata could increase contraction frequency and contraction tension in normal small intestine in vitro comparing with normal small intestine ( p < 0.01 or p < 0.05) , gynura divaricata could also increase contraction frequency and contraction tension in inhibition small intestine by atropine in vitro comparing with inhibition small intestine by atropine ( p < 0.01 or p < 0.05 ) .Conclusion:Gynura divaricata could improve the function of gastrointestinal motility in mice.
-
[1] 广东植物研究所.海南植物志[M].北京:科技出版社, 1974:416. [2] 江苏新医学院.中药大辞典[M].上册.上海:上海人民出版社, 1977:756. [3] 胡勇, 李维林, 林厚文, 等.白背三七地上部分的化学成分[J].中国天然药物, 2006, 4 (2) :156-158. [4] 姜曼花, 邱细敏, 刘胜姿, 等.白背三七多糖的提取纯化及含量测定[J].时珍国医国药, 2008, 19 (9) :2147-2149. [5] 胡勇, 李维林, 林厚文, 等.白背三七地上部分降血糖作用研究[J].西南林学院学报, 2007, 27 (1) :55-58. [6] 接敏, 万春鹏, 余燕影, 等.白背三七大孔树脂富集物化学成分及抗氧化活性研究[J].天然产物研究与开发, 2012, 24 (2) :155-159, 163. [7] 陈贤兴.白背三七草的诱变及抗诱变作用的初步研究[J].河南科学, 2002, 20 (3) :261-263. [8] 陈镇, 夏泉, 黄赵刚.白术挥发油对小鼠胃肠功能的影响[J].中国实验方剂学杂志, 2009, 15 (8) :66. [9] 吴旻丹, 陈瑜, 金邦荃.猕猴桃提取物促进小鼠离体肠断运动的初探[J].食品工业科技, 2011, 32 (1) :78-80. [10] 王婧, 潘盛武, 杨盛昌.银杏叶提取物对小鼠离体小肠平滑肌收缩特性的影响[J].四川动物, 2009, 28 (3) :382-385. [11] 李茜, 关玥, 马会杰, 等.三七总皂苷对家兔离体小肠平滑肌自发收缩活动的影响[J].中国应用生理学杂志, 2010, 26 (1) :117-120. [12] 马正东, 陈磊, 宋洪涛, 等.白背三七水提取物对2型糖尿病大鼠的降血糖作用及其机制[J].中草药, 2010, 41 (4) :623-626. [13] Pan SY, Han YF.Comparsion of the inhibitory efficacy of four belladonna drugs on gastrointestinal movement and cognitive function in food-deprived mice[J].Pharmacology, 2004, 72 (3) :177-183.
计量
- 文章访问数: 112
- HTML全文浏览量: 10
- PDF下载量: 420
下载:
