Abstract: Antioxidant activity of polyphenols was studied for peanut red skins. Ethanol, acetone, distilled water were used as extraction solvent for polyphenols from peanut red skins. The antioxidant capacity of polyphenols extracts were determined by the total antioxidant capacity (T-AOC) testing, superoxide radical scavenge ability and hydroxyl radicals scavenge ability. The antioxidant activity in vitro of these three polyphenols extracts was compared and the total polyphenols content was determined. The results showed that the total polyphenols content of three polyphenols extracts was at 9.7% , 9.2% and 6.3% . In the different antioxidant system, three kinds of polyphenol extracts had good antioxidant activity, which 60% ethanol extracts oxidation capacity was higher than the volume fraction of 0.02% V C . The order of the three oxidation capacity were 60% ethanol extracts>60% acetone extracts>distilled water extracts.