Medicinal and Nutritional Value of the Chemical Compositions of <i>Dioscorea opposita</i> Thunb. cv. Tiegun Peel Based on UPLC-Q/TOF-MS/MS and Bioinformatics

AN Li; WANG Hong; MA Jingwei; YUAN Yongliang; ZHAI Nannan; ZHENG Lufei; WU Xujin

doi:10.13386/j.issn1002-0306.2021100320

Volume 44 Issue 2

Jan. 2023

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Science and Technology of Food Industry > 2023 > 44(2): 1-9. > DOI: 10.13386/j.issn1002-0306.2021100320

AN Li, WANG Hong, MA Jingwei, et al. Medicinal and Nutritional Value of the Chemical Compositions of Dioscorea opposita Thunb. cv. Tiegun Peel Based on UPLC-Q/TOF-MS/MS and Bioinformatics[J]. Science and Technology of Food Industry, 2023, 44(2): 1−9. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2021100320.

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Medicinal and Nutritional Value of the Chemical Compositions of Dioscorea opposita Thunb. cv. Tiegun Peel Based on UPLC-Q/TOF-MS/MS and Bioinformatics

1.
Institute of Quality Standard and Testing Technology for Agro-products, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China
2.
Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
3.
SCIEX China, Beijing 100015, China
4.
Institute of Quality Standard and Testing Technology for Agro-products, Chinese Academy of Agricultural Sciences, Beijing 100081, China

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Received Date: October 31, 2021
Available Online: November 06, 2022

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Abstract

Abstract

Objective: Systematic analysis and identification of chemical constituents of Dioscorea opposita Thunb. cv. Tiegun peel, and exploration of its medicinal and nutritional value. Methods: Ultra-high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UPLC-Q/TOF-MS/MS) was performed to analyze the chemical compositions of Dioscorea opposita Thunb. cv. Tiegun peel. The compounds were identified based on their primary and secondary mass spectrometry information and compared with the related references and databases. Further, bioinformatics was applied to predict the targets of potential active ingredients, enrich Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, screen out the important targets, and explore its potential mechanism. Results: 33 compounds were identified such as apigenin, acacetin, liquiritigenin, batatasin I, which were considered to be the potentially vital compounds. Pathway enrichment analysis indicated that Dioscorea opposita Thunb. cv. Tiegun peel exerted medicinal effects by regulating cell signaling pathways, cancer, metabolic and other disease-related pathways. Conclusion: In this study, UPLC-Q/TOF-MS/MS combined with bioinformatics were used, which would provide an important reference for the identification of ingredients, selection of active compounds, discovery of potential medicinal nutritional value, as well as further development and utilization of Dioscorea opposita Thunb. cv. Tiegun peel.
- Dioscorea opposita Thunb. cv. Tiegun peel,
- UPLC-Q/TOF-MS/MS,
- chemical composition,
- bioinformatics,
- mechanism

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References (33)

References

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