Determination of Residues of Diuretics in Chicken and Swine by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry

XUE Ying; HUA Jin; GAO Hao; DU Lijun; XU Yao; HUANG Liting; WANG Jiani

doi:10.13386/j.issn1002-0306.2020050206

Volume 42 Issue 3

Jan. 2021

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Science and Technology of Food Industry > 2021 > 42(3): 230-235. > DOI: 10.13386/j.issn1002-0306.2020050206

XUE Ying, HUA Jin, GAO Hao, DU Lijun, XU Yao, HUANG Liting, WANG Jiani. Determination of Residues of Diuretics in Chicken and Swine by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry[J]. Science and Technology of Food Industry, 2021, 42(3): 230-235. DOI: 10.13386/j.issn1002-0306.2020050206

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Determination of Residues of Diuretics in Chicken and Swine by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry

1. Taiyuan Customs Technology Center, Taiyuan 030024, China;
2. Agricultural and Food Industry, Shaanxi Provincial Product Quality Supervision and Inspection Institute, Xi'an 710048, China

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Received Date: May 17, 2020
Available Online: February 02, 2021

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Abstract

Objective:An ultra-high performance liquid chromatography-tandem mass spectrometry method for detection of furoxime,spironolactone and bumetanilan in chicken and swine,which were banned in animal-derived foods,was established. Methods:The samples were purified with C₁₈ powder after the extraction of ethyl acetate. The chromatographic column was Hypersil GOLD C₁₈(1.9 μm,2.1 mm×50 mm).Mobile phase was acetonitrile and 0.1% formic acid water. The flow rate was 0.4 mL/min,and the column temperature was 40 ℃. The electrospray was operated in both positive and negative mode at the same time and the samples were detected by multiple reaction monitoring(MRM).Results:The liner relations of the three diuretics were good within the concentration range of 1.0~500.0 μg/L(r>0.996). The average standard recovery rate was 67.3%~111.6%. Limits of detection of the method were 0.5 μg/kg and limits of quantification were 1.0 μg/kg. Conclusion:This method is simple and accurate,and can be used as a rapid method for detection of diuretics in chicken and swine.
- chicken,
- swine,
- diuretics,
- furoxime,
- spironolactone,
- bumetanilan,
- ultra-high performance liquid chromatography-tandem mass spectrometry

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Determination of Residues of Diuretics in Chicken and Swine by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry