Abstract: The beer industry is one of the most rapidly developing industries in Chinese beverage alcohol industry, in which the production of raw materials and processing of beer are closely related to the quality of products and industrial development. The control of Deoxynivalenol (DON) from contamination of raw materials or processing of beer is one of the most critical and interesting research areas. This paper analyzes the contamination of DON, which is an important mycotoxin that affects the quality and safety of beer. Combined with the migration and transformation of DON during the key stages of beer processing, the measures for controlling DON in beer processing are elaborated from three major methods of physics, chemistry and biology, which provides the theoretical basis for controlling DON contamination and improving the quality of beer.