Abstract: In order to explore the best preparation technology and release performance of Artemisia selengensis flavonoids microcapsules, the molecular embedding method was used with Artemisia selengensis flavonoids as the core material, β-Cyclodextrin as the wall material, and the preparation technology of microcapsules was optimized by single factor and response surface methodology. By measuring the retention rate of flavonoids in microcapsules at different temperatures and relative humidity, Avrami’s formula was used to fit the release kinetics of microcapsules under different conditions. Meanwhile, the release rate constant and release mechanism parameters were analyzed. The results showed that the optimal preparation parameters of Artemisia selengensis flavonoids microcapsule were as follows: Embedding time 65 min, embedding temperature 55 ℃, core/wall material quality ratio 1:3 (g/g), the embedding rate of microcapsule could reach 89.52%. The release kinetics of microcapsules was between diffusion limited kinetics and first-order kinetics under the conditions of 4, 25, 45 ℃ and 50%, 70%, 90% relative humidity. In addition, the release rate constant increased with the increase of temperature and humidity. Therefore, low temperature and humidity will be more conducive to the preservation and sustained release of Artemisia selengensis flavonoids microcapsules. The results provide the theoretical basis for the research and development of Artemisia selengensis flavonoids and related functional food.