Abstract: Food safety city is an important vehicle to promote the level of food safety and the satisfaction degree for local government. The article made use of the qualitative comparative analysis to analyze the mechanism of multiple factors in the eleven food safety founding cities of Zhejiang province. The results showed that qualitative comparative analysis on the feasibility of establishing public satisfaction promotion research field in food safety city. The public's evaluation of government supervision was the necessary condition to affect the satisfaction degree. The five conditional variables of food safety publicity, qualified rate of food sampling, good water quality index, per capita GDP and tobacco and alcohol consumption price index interact to improve the satisfaction degree. The low per capita GDP, strong publicity on food safety or good water could improve the satisfaction degree. It was found that the impact factors of the food safe founding city were positively correlated with the satisfaction degree. Every time the creation factor increased by 1 standard unit, the public satisfaction with food safety would increase by 0.687 units. The conditional configuration and result analysis showed that there were three paths to upgrade the satisfaction degree of propaganda and developments, resource endowment and low economic driven type.