Abstract: The objective of this study was to explore the anti-aging effects of peptide from Antarctic krill on the skin of Kunming mice. The mice were randomly set as follows: Normal control group, model control group, group of Antarctic krill peptide (P-1), group of Antarctic krill peptide (P-2). Then characteristics and biochemical criterion analyzing were measured after mice were executed. The results showed that the skin of animals in P-1 and P-2 groups was similar to that of animals in model control group, showing elastic light wrinkled. Compared with the model group, the P-1 and P-2 groups significantly reduced water loss (P<0.01), significantly decreased levels of GAG, collagen breakdown of photoaging skin and lipid loss (P<0.05); the P-1 and P-2 groups significantly enhanced activity of T-SOD, CAT, GSH-Px and decreased levels of MDA in serum (P<0.05). This study showed that peptide from Antarctic Krill could protect skin against UV irradiation-induced photodamage. It provided a theoretical basis for the application of peptide from Antarctic Krill in the field of cosmetics.