Abstract: Coenzyme Q10 is a fat-soluble vitamin-like benzoquinone compound, which is synthesized endogenously from tyrosine in human body. It has many physiological functions, such as participating in ATP production capacity, scavenging free radicals and anti-oxidantion, enhancing immunity, stabilizing cell membranes and so on. Since the first coenzyme Q10 health food was approved in 2003, and by 2020, coenzyme Q10 was used as raw material for record management. China has approved 171 coenzyme Q10 health foods. In order to better understand the current situation of approved coenzyme Q10 health foods, the author took the research work of coenzyme Q10 health food raw materials list project which I participated in tracking as the starting point, based on the original China Food and Drug Administration website and the date of approved products from 1996 to 2020 published on the website of the State Administration of Market Supervision, combined with the actual registration review work and related research status, comprehensively analyzed the review and approval of coenzyme Q10 health foods in the past 20 years from the aspects of safety, function claims, and quality control. The author also proposed some opinions and suggestions on strengthening the study of the published coenzyme Q10 raw material catalogue, and to explore the inclusion of amino acids, probiotics, protein and other dietary nutrients into the raw material catalogue management, pay attention to the construction of the exclusive quality standard system of dietary supplement raw materials.