Abstract: Non-intentional added substances (NIAS) would be introduced into food contact materials (FCMs) in the process of production, use and recycling. NIAS have brought the severe challenges to the safety assessment and supervision of FCMs due to their complexity and unascertainty. In recent years, as one of the important factors affecting food safety, the migration of NIAS in FCMs has attracted much attention. In this paper, the research procedure, classification and main origins of NIAS in FCMs are briefly introduced, the major analysis strategy of NIAS is summarized base on the target and research purpose.In addition, the recent progress of main NIAS and their possible origins in different types of FCMs are focused. This review is expected to provide scientific guidance for future studies of NIAS in FCMs.