Abstract: Objective: Inductively coupled plasma mass spectrometry (ICP-MS) was established for the determination of nine heavy metal elements in livestock and poultry meat, and was applied to the analysis of heavy metal content in seven kinds of livestock and poultry meat samples.Methods: The samples were pretreated with graphite digestion, and heavy metals were detected by ICP-MS.Results:Chromium, lead, arsenic, cadmium, and cobalt (0～50 μg/L), copper, manganese and nickel (0～500 μg/L), and zinc (0～1000 μg/L) showed a good linear relationship (r≥0.9999). The limits of detection were ranged from 0.003 to 0.400 μg/L, the recoveries ranged from 97.2% to 104.4%, RSD≤5.0%(n=6). The results of National Standard Substance (GSB-27, GSB-28) were all within the standard deviation of the standard value.Conclusion:The proposed method had a wide linear range, high accuracy and precision, which was suitable for the monitoring of livestock and poultry meat. This study provided a scientific basis for the safety evaluation, establishment and operation of the supervision system of livestock and poultry in Guangzhou.