Abstract: Objective: To investigate the radioprotective effect of jackfruit protein peptide and collagen peptide with pleasant mouthfeel in many bioactive peptides in ⁶⁰Co γ ray-irradiated mice. Methods: Two hundred and eighty eight specific pathogen free (SPF) female BALB/c mice were randomly divided into 4 batches with 6 groups and 12 rats in each group. Each batch divided into blank control group, model control group, 2 jackfruit protein peptide intervention groups (0.20, 0.80 g/kg BW) and 2 collagen peptide intervention groups (0.53, 1.6 g/kg BW). After the 26 days of the intragastric administration, the mice except the blank control group received ⁶⁰Co γ-ray whole body irradiation, and intragastric intervention continued after irradiation. The number of peripheral blood white blood cells (radiation dose 3.5 Gy, 3 and 14 days after irradiation), bone marrow DNA content and the content of 8-OhdG in serum (radiation dose 3.5 Gy, 3 days after radiation), serum hemolysin (radiation dose 1 Gy, 7 days after radiation) and superoxide dismutase (SOD) activity in blood (radiation dose 7 Gy, 7 days after radiation) were measured, respectively. Results: Compared with the model control group, the number of peripheral blood white blood cells in high dose of jackfruit peptide, and low and high dose of collagen peptide were significantly increased on 3rd day after radiation (P<0.05). The number of peripheral blood white blood cells in high dose of jackfruit peptide, and high dose of collagen peptide were significantly increased on 14th day after radiation (P<0.05). Bone marrow DNA content in high dose of jackfruit peptide were significantly increased on 3rd day after radiation (P<0.05). The high-dose group of jackapple peptide and the high-dose group of collagen peptide could significantly reduce the 8-hydroxydeoxyguanosine content in mouse serum after irradiation (P<0.01). Serum hemolysin were significantly increased on 7th day after radiation (P<0.05). Conclusion: Jackfruit peptide had protective effects against ionizing radiation exposure. Collagen peptides improved the number of peripheral blood white blood cells damaged by ionizing radiation and reduce the content of 8-hydroxydeoxyguanosine in mouse serum after radiation.