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中国精品科技期刊2020

葛仙米对大鼠的润肠通便作用研究

刘银路, 毕萃萃, 魏芬芬, 陈盛, 王玉兰, 张波

刘银路, 毕萃萃, 魏芬芬, 陈盛, 王玉兰, 张波. 葛仙米对大鼠的润肠通便作用研究[J]. 食品工业科技, 2020, 41(16): 292-296. DOI: 10.13386/j.issn1002-0306.2020.16.046
引用本文: 刘银路, 毕萃萃, 魏芬芬, 陈盛, 王玉兰, 张波. 葛仙米对大鼠的润肠通便作用研究[J]. 食品工业科技, 2020, 41(16): 292-296. DOI: 10.13386/j.issn1002-0306.2020.16.046
LIU Yin-lu, BI Cui-cui, WEI Fen-fen, CHEN Sheng, WANG Yu-lan, ZHANG Bo. Effect of Nostoc sphaeroides on Laxative in Rats[J]. Science and Technology of Food Industry, 2020, 41(16): 292-296. DOI: 10.13386/j.issn1002-0306.2020.16.046
Citation: LIU Yin-lu, BI Cui-cui, WEI Fen-fen, CHEN Sheng, WANG Yu-lan, ZHANG Bo. Effect of Nostoc sphaeroides on Laxative in Rats[J]. Science and Technology of Food Industry, 2020, 41(16): 292-296. DOI: 10.13386/j.issn1002-0306.2020.16.046

葛仙米对大鼠的润肠通便作用研究

详细信息
    作者简介:

    刘银路(1992-),男,硕士研究生,研究方向:生物活性物质的功能与毒理,E-mail:181083210416@buu.edu.cn。

    通讯作者:

    张波(1962-),女,博士,教授,研究方向:生物活性物质的功能与毒理,E-mail:zhangbo_wl@buu.edu.cn。

  • 中图分类号: TS201.2

Effect of Nostoc sphaeroides on Laxative in Rats

  • 摘要: 目的:研究葛仙米对便秘大鼠的润肠通便作用,并探讨其缓解便秘的相关机制。方法:随机将大鼠分为对照组、模型组、葛仙米组。模型组、葛仙米组灌胃葛仙米3周后再灌胃盐酸洛哌丁胺1周,对照组大鼠灌胃等量生理盐水。灌胃墨汁实验观察大鼠首粒排黑便时间。采用苏木精-伊红(Hematoxylin-eosin,HE)染色和阿利新蓝-过碘酸雪夫(Alcian blue-periodic acid Schiff,AB-PAS)染色,观察结肠结构以及粘液物质分泌情况。结果:与模型组大鼠比较,葛仙米组大鼠经葛仙米干预,极显著增加了便秘大鼠的粪便重量以及含水量(P<0.01);极显著缩短了首粒黑便产生时间(P<0.01);显著改善了结肠肌层和粘膜层结构,增加杯状细胞数量以及粘液物质含量(P<0.05)。结论:葛仙米通过显著增加大鼠大肠水分含量,加强肠蠕动,增加黏液分泌,对肠道组织保护具有促进作用,在本实验中具有较好的润肠通便作用。
    Abstract: Objective:To study the effect of Nostoc sphaeroides on laxative in constipation rats and explore the related mechanisms of relieving constipation. Methods:Rats were randomly divided into control group,model group and Nostoc sphaeroides group. The model group and the Nostoc sphaeroides group were intragastrically administered with Nostoc sphaeroides for 3 weeks and then administered with loperamide hydrochloride for 1 week. The rats in the control group were given the same amount of normal saline. The first black sputum time was observed by intragastric administration of the ink. Hematoxylin-eosin(hematoxylin-eosin,HE)staining and alixin blue-periodic acid Schiff(AB-PAS)staining were used to observe colonic structure and mucus secretion. Results:Compared with the model group rats,Nostoc sphaeroides group's intervention with Nostoc sphaeroides extremely significantly increased the fecal weight and water content of constipated rats(P<0.01),and extremely significantly shortened the first black stool generation time(P<0.01). The structure of the colonic muscular and mucosal layers was improved,the number of goblet cells and the content of mucus increased significantly(P<0.05). Conclusion:Nostoc sphaeroides could significantly improve the intestinal water content,strengthen intestinal peristalsis,increase mucus secretion,protect intestinal tissues,and effectively improve constipation symptoms.
  • 期刊类型引用(1)

    1. 李彩霞,孙霞,王雪莲,赵丽娟,皮立,魏立新. 不同提取方法对甘松精油品质和成分的影响. 中国野生植物资源. 2024(10): 49-58 . 百度学术

    其他类型引用(1)

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  • 被引次数: 2
出版历程
  • 收稿日期:  2019-09-11
  • 网络出版日期:  2020-11-12
  • 刊出日期:  2020-08-14

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