Abstract: Objective:The mice model of alcoholic oxidative damage was used to observe the antioxidant effect of American ginseng tea and its protective effect on liver injury. Methods:Mice were randomly divided into control group,model control group,low,medium and high(0.275 g,0.550 g,1.100 g crude drug/kg)doses of American ginseng tea group,American ginseng drink tablets soaking water group(0.500 g crude drug/kg),detection of malondialdehyde(MDA),protein carbonyl(PC),total superoxide dismutase(T-SOD),reduced glutathione(GSH)levels in serum and liver homogenate,as well as alanine aminotransferase(ALT),aspartate aminotransferase(AST)and triglyceride(TG)levels in serum,and pathological changes in liver tissue were observed. Results:Compared with the model group,American ginseng tea doses dependently reduced MDA and PC levels(P<0.01),increased T-SOD(high dose P<0.01,serum of low and medium doses P<0.05)and GSH(P<0.01)levels in serum and liver tissue,decreased ALT,AST(P<0.01)and TG(medium and high doses P<0.01,low dose P>0.05)levels in serum,and improved pathological changes in liver tissue such as liver cell necrosis,vacuolar degeneration and inflammatory infiltration. Conclusion:American ginseng tea has good anti-oxidation effect and prevents liver damage.