Abstract: To investigate the effect of chitooligosaccharides compound solid beverage on glucose and lipid metabolism in mice with type 2 diabetes(T2DM),seventy mice were randomly divided into normal control group(NFD),model group(T2DM),positive control group(T2DM+Acar),chitooligosaccharides group(T2DM+COS),and Ke Tang Ping groups with low(T2DM+LKTP),middle(T2DM+MKTP),high dose(T2DM+HKTP). After being treated for 4 weeks,serum levels of TC,TG,LDL-C,HDL-C,ALT and AST were detected. The results showed that Ke Tang Ping could significantly increase the body weight of T2DM,decrease serum glucose,TC,TG and LDL-C,AI,liver and cardiac index,ALT and AST(P<0.05).At the same time,it could also markedly inhibit the pathological damage of liver and kidney. Protein and mRNA levels in mouse liver tissue were determined. Finally,compared with the T2DM group,some key enzymes in glycolipid metabolism were regulated by Ke Tang Ping,SREBP-2,HMGCR,G6pase and PEPCK were significantly down-regulated,whereas CYP7A1 and LDLR were up-regulated after the treatment of Ke Tang Ping(P<0.05). Taken together,Ke Tang Ping could reduce blood lipid and blood glucose in T2DM mice.