Abstract: In this study,Kunming male mice were selected to explore the effects of grape skin extracts(GSE)on arsenic-induced reproductive toxicity. The reproductive toxicity was induced by 10 mg/L arsenic in drinking water,and was intervened with 4.5 mg GSE/kg·BW in Kunming male mice.After 60 days of treatment,arsenic intake caused testicular organ coefficient decrease significantly(P<0.05),pathological changes of testis structure occurrence,and sperm quality and quantity decrease significantly(P<0.05). Meanwhile,the activity of superoxide dismutase(SOD)and the content of reduced glutathione(GSH)declined significantly(P<0.05),the contents of H₂O₂ and malonedialdehyde(MDA)significantly increased in testicular tissues in arsenic exposure group(P<0.05). After intervention with GSE,arsenic-caused decrease in testis-body ratios was inhibited,and the damage to testicular tissue structure was alleviated along with the increase of total sperm counts and the decrease of sperm deformity in comparision with arsenic group(P<0.05). Furthermore,GSE intervention caused significant increases of SOD activity and GSH content,and the obvious decreases of H₂O₂ and MDA contents in testicular tissues(P<0.05).These results indicate that GSE can alleviate the reproductive toxicity of arsenic,and improve the antioxidant capacity of mouse testis,demonstrating a protective effect on male reproductive function against arsenic intake.