Abstract: Objective:To explore the protective effect of sialic acid on acute ethanol-induced oxidative damage in mice. Method:The experimental animals were randomly divided into five groups(control group,model group,low,medium and high dose sialic acid group(15,30 and 60 mg/kg·bw)according to the body weight. Except the control group,the other four groups were given 50% ethanol orally after 30 d administration to establish an ethanol-induced oxidative damage model. To study the antioxidant activity,serum and liver tissues were selected to detect the corresponding indicators,such as the activity of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px),the contents of glutathione(GSH),malondialdehyde(MDA)and protein carbonyl(PC). Results:The sialic acid could significantly reduce the contents of both MDA and PC(P<0.05),and significantly increase the activity of GSH-Px and SOD as well as the content of GSH(P<0.05). Conclusion:The sialic acid has a protective effect on acute oxidative damage of ethanol in mice.