Abstract: Ultra-high performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)was established for the detection of 15 kinds of sulfonamides and 6 kinds of fluoroquinolones residues in the Sansui duck. Based on this method,the residual risks of 21 analytes were evaluated. The standard curve for 21 analytes showed a good linear relationship with the concentration range of 5~200 μg/L,correlation coefficient were more than 0.990,and the limit of detection(LOD)were 0.5~2.0 μg/kg,limit of quantitation(LOQ)were 2.0~5.0 μg/kg,and the recovery rate were 70.3%~113.2%,and relative standard deviation(RSD)were 2.1%~11.5%(n=6)when the amount was 5~50 μg/kg. This method was simple,quick,with a better precision,higher accuracy,and could be applied to detect the two types of veterinary drug residues in duck. No fluoroquinolones drugs in the Sansui duck were detected. The results showed that the sulfachloropyridazine residues belonged to sulfonamides were at a rate of 2.17%,ranged from 2.37 μg/kg to 3.68 μg/kg with an average value of 3.33 μg/kg,not exceeding the maximum residue limits set by the state(100 μg/kg),and other sulfonamides were not detected. Refer to the international regulations on ADI value of sulfonamides,the average value of food safety index in sansui duck products related to sulfachloropyridazine residues was 0.00014,the minimum value was 0.00010,the maximum was 0.00016,which was far below 1.It showed that the potential hazard level of the fluoroquinolones and sulfonamides residues in sansui duck is acceptable.