Abstract: In order to determine the optimal process of apple polyphenol microcapsules,improve the resistance and sustained-release ability of apple polyphenols to adverse environment,response surface methodology was used to optimize the technology of apple polyphenol microcapsules by using sodium alginate,chitosan and calcium chloride as wall materials and embedding rate as response value. Then the tolerance of the optimized microcapsules in simulated artificial gastric juice and intestinal juice were analyzed. The results showed that sodium alginate concentration,calcium chloride concentration,pH and core-wall ratio had significant effects on apple polyphenol embedding rate. The embedding rate of apple polyphenol microcapsules reached 85.13% when sodium alginate concentration was 0.020 g/mL,calcium chloride concentration was 0.040 g/mL,pH was 7.0 and core-wall ratio was 2:1. Microcapsule products could reduce the damage of apple polyphenols in the gastrointestinal tract,they were well released in simulated gastric and intestinal fluid environments. The maximum release rate in intestinal fluid was 83.00%. The experimental results showed that the method was simple and feasible,it could effectively improve the embedding rate and sustained-release capacity of apple polyphenol microcapsules.