Abstract: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) plays an important role in screening and confirming analysis of multiple pesticides for food, with high throughput and high efficiency. In this paper, the application of LC-MS/MS technology based on quadrupole mass filter in pesticide multiresidue analysis for food in recent years is reviewed. The main attention in this review is focused on the application of liquid chromatography-low resolution tandem mass spectrometry (triple quadrupole tandem mass spectrometry and quadrupole-linear ion trap tandem mass spectrometry) and liquid chromatography-high resolution tandem mass spectrometry (quadrupole-time-of-flight tandem mass spectrometry and quadrupole-orbitrap tandem mass spectrometry) in the simultaneous analysis of multiple types of pesiticide residues.