Abstract: Food-derived immune active peptide have the advantages of being avirulence,low allergic,and high safety. They have a wide source of food-derived proteins and are easy to draw materials. The immune active peptides play an irreplaceable role in human nutrition health and disease regulation. With the development of science and technology,the value of food-derived immune active peptide has attracted widespread attention from scholars around the world. It has gradually been added to new functional foods and clinical treatment. In this paper,basing on the analysis of the relationship between food-derived immune active peptide and clinical and life applications,from the aspects of the selection of food-derived protein and preparation methods and conditions,according to plant-derived immune active peptide,animal-derived immune active peptide,microbial-derived immune active peptide and microbial fermentation preparation,the research status of food-derived immune active peptide and the research trends of food-derived immune active peptide were reviewed in five aspects,including the enzyme hydrolysis method and microbial fermentation.