Abstract: Pinctada fucata is the main economic shellfish in marine pearl aquaculture industry. The antioxidant peptides from Pinctada fucata have been a research hotspot in recent years. In this paper, it was reviewed that the enzymatic preparation technology, separation and purification technology, functional properties and application research status of antioxidant peptides derived from Pinctada fucata in domestic and foreign in recent years. The development status and existing problems of antioxidant peptides derived from Pinctada fucata were remarked.The modern genetic engineering technology in the application prospects of antioxidant peptides of Pinctada fucata was further analyzed.It is intended to provide useful information for further efficient exploitation and utilization of antioxidant peptides of Pinctada fucata and other new marine active peptide.