Abstract: The peptide-mineral chelate, which is a new kind of compound obtained from the chelation reaction between peptides and mineral ion.It can not only enhance the absorption of minerals, but also possess some biological activities, such as antioxidant, immune enhancement and hypoglycemic capabilities.This review outlined the research status of chelate compounds, and its chelation mechanism, preparation procedure, safety assessment and bioactivity. The development prospect of peptide-mineral chelate was analysed in the last.