Abstract: The Aronia melanocarpa enzyme was fermented by Lactobacillus,the changes of total phenols,antioxidant activities during fermentation process and anti- aging effect were investigated by the aging mice induced by D- galactose. The result showed that comparing with before fermentation,with the increase of fermentation time the content of total phenols,superoxide anion scavenging activity and DPPH·scavenging activity increased 2.42,1.69,0.088 times,the in vitro antioxidant activity of Aronia melanocarpa enzyme was significantly enhanced( p < 0.05). Compared with the model group and unfermented group,the index of body weight and immune organs,activities of T- SOD,CAT,scavenging ratio of·OH radicals in plasma and liver of fermented group were significantly increased( p < 0.05).In addition,the content of MDA significantly reduced( p < 0.05). The results showed that the Aronia melanocarpa enzyme had anti- oxidant effect on aging model mice.