Abstract: Objective: To study the effect of the Fructus phyllanthi on the human saliva flow rate,p H and bacterial.Methods: The saliva both before and after chewing form 10 volunteers were collected,the saliva flow rate and pH change were determined and the total bacteria and Streptococcus mutans content in saliva were detected using real- time PCR experiment. Results: Compared with the results before chewing,volunteers saliva flow rate was increased significantly after chewing Fructus phyllanthi,the pH was decreased first and then increased,the number of total bacteria and S. mutans were decreased. Conclusion: Fructus phyllanthi could promote human saliva secretion,and effectively reduce the number of total bacteria and S.mutans in the oral,there was a certain effect on the prevention of dental caries.