Abstract: Based on the method of traditional solvent extraction,the proanthocyanidins contents of Lycium ruthenicum from different producing areas was determined by spectorphotometry with vanillin- Hydrochloric acid as the color- developing agent. The anthocyanins contents were determined by extinction coefficient method. The results showed that proanthocyanidins and anthocyanin content range was 14.26~90.24 mg / g and 0.69~8.40 mg / g( dry powder).It meant that the content of proanthocyanidins was significantly higher than that of anthocyanins.The content of proanthocyanidins from wild L.ruthenicum in Golmud Qinghai was significantly higher than that in other places,in which the contents were Aksu Xinjiang > Nomhon Qinghai > Kuerle Xinjiang > Ejinaqi Inner Mongolia.The content of proanthocyanidins from cultivated L. ruthenicum in Golmud Qinghai was significantly higher than that from wild L.ruthenicum( p < 0.05).It showed that artificial cultivation of L.ruthenicum was a better way.The contents of proanthocyanidins and anthocyanins from cultivated L.ruthenicum in Beijing can be equal to those in the origin under the condition of abundant water,light and fertilizer.