Abstract: To optimize the extraction technology of anthocyanin from Lycium ruthenicum by pectinases.The pectinase extraction techeques of anthocyanin by response surface methodology were studied on the basis of single factor test. The result showed that the optimal extraction conditions were as follows: the pectinase adding amount 70 mg /100 g( mass fraction),hydrolysis temperature 41 ℃,and ahydrolysis time 1 h.Under the optimal extraction conditions,the extraction rate of anthocyanin from Lycium ruthenicum was 63.70% and the extraction amount was 215.31 mg /100 g,consistent with the predicted 63.01%,which was increased by 43.42%,compared with the non- using pectinase samples.The optimal extraction conditions by response surface enzyme method were benefit to improve the anthocyanins extraction rate from Lycium ruthenicum.