Abstract: In order to study the protective effect of Lingonberry extraction on chronic stressed mice,total 60 male Kunming mice were randomly divided into 6 groups :normal control group,stressed model group,positive group( Fluoxetine 4. 4 mg / kg·d), experience group( low, medium, high dose were 50, 100, 200 mg / kg·d respectively). Use the chronic stress animal model to research anti stress effect of Lingonberry in behavior and physiology. Compared with control group,model mice immobility duration significantly prolonged in tail suspended test(p<0.05),cerebral SOD,GSH-Px and 5-HT decreased(p<0.05),MDA increased(p<0.05),serum NE and 5-HT decreased(p <0.05),GC and ACh E increased(p <0.01,p <0.05 respectively). Compared with model group,the mice of high dose group immobility duration significantly shortened in tail suspended test,low dose group mice cerebral MDA reduced(p<0.05),high dose mice cerebral SOD,high and low dose group mice cerebral 5-HT,and low dose group cerebral tissue GSH-Px content increased(p<0.05). High dose group serum GC and ACh E decreased(p <0.01,p <0.05),middle dose group serum 5-HT increased(p <0.05). In conclusion,Lingonberry can greatly protect the body,reduce the adverse effects of chronic stress on mice.