Abstract: Vitamin E has two subfamilies,including tocopherols and tocotrienols and each subfamily has four monomers( α,β,γ and δ).Compared to other vitamin E monomers,γ- tocotrienol( γ- T3) has a better anti- tumor,neuroprotection,lower cholesterol,inhibition to fat production and other anti- inflammatory effect. The biological activity and mechanism of γ- T3 were reviewed,the existing problems of γ- T3 biological activity was put forward and the research direction was forecast.