Abstract: Objective: To explore the effects of the aqueous extract of okra on the blood glucose and lipid profiles in type 2 diabetes mellitus( T2DM) rats.Methods: The male SD rats were randomly divided into normal control group and experimental groups according to the body weight.The rats in the two groups were fed with lab chow and high- sugar and high- fat diet respectively. After four weeks of feeding,the rats in the experimental group received peritoneal injection of streptozotocin( STZ). Based on the glucose level,the succeed model rats were randomly re- grouped as blank control,positive control( Jiangtangning gavage,0.64 g / kg),high,middle,and low dose of okra extract groups( the okra extract was added into the high fat diet at the dosages of 2.60 g / kg,1.56 g / kg,and0.78 g / kg respectively).The experiment lasted for four weeks.Body weight,average levels of food and water,and blood glucose level were measured weekly.At the end of experiment,the blood samples of the rats were collected and analyzed for serum glucose,triglyceride( TG),total cholesterol( TC),high density lipoprotein cholesterol( HDL-C),and low density lipoprotein cholesterol( LDL- C).Results: The serum glucose was lower in the rats of high dose group than that in blank control group and low does group( p < 0.05,p < 0.05).Serum TC was lower in all okra feeding groups of rats than those in blank control group( p < 0.01).Serum LDL- C level was lower in high dose group rats than that in blank control group( p < 0.01). Conclusion: The aqueous extract of okra can markedly decline serum glucose and lipid in T2 DM rats.