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中国精品科技期刊2020
刘萌, 吴永沛, 刘翼翔, 陈海秀. 棕榈酸与油酸影响肝细胞功能的比较研究[J]. 食品工业科技, 2016, (03): 347-350. DOI: 10.13386/j.issn1002-0306.2016.03.064
引用本文: 刘萌, 吴永沛, 刘翼翔, 陈海秀. 棕榈酸与油酸影响肝细胞功能的比较研究[J]. 食品工业科技, 2016, (03): 347-350. DOI: 10.13386/j.issn1002-0306.2016.03.064
LIU Meng, WU Yong- pei, LIU Yi- xiang, CHEN Hai-xiu. A comparative study of palmitic acid and oleic acid on liver cell function[J]. Science and Technology of Food Industry, 2016, (03): 347-350. DOI: 10.13386/j.issn1002-0306.2016.03.064
Citation: LIU Meng, WU Yong- pei, LIU Yi- xiang, CHEN Hai-xiu. A comparative study of palmitic acid and oleic acid on liver cell function[J]. Science and Technology of Food Industry, 2016, (03): 347-350. DOI: 10.13386/j.issn1002-0306.2016.03.064

棕榈酸与油酸影响肝细胞功能的比较研究

A comparative study of palmitic acid and oleic acid on liver cell function

  • 摘要: 膳食中不平衡的脂肪酸摄入导致一系列慢性代谢综合征的产生,严重威胁人体健康。以体外肝细胞模型为研究对象,以细胞增殖、细胞膜完整性、炎症产生水平及胞内脂质累积为指标,通过比较油酸和棕榈酸对肝细胞功能的影响,以期评估过量膳食脂质对人体健康的影响,减少慢性病的产生。结果表明不同膳食脂肪酸对肝细胞的影响明显不同:棕榈酸的细胞毒性大,抑制细胞的增殖,破坏细胞膜的完整性,容易导致肝炎发生;油酸则更容易导致肝细胞脂质累积,引起脂代谢异常;复合脂肪酸(油酸∶棕榈酸的摩尔比为2∶1)的细胞毒性有所下降,但仍然容易导致肝细胞脂肪变性。实验结果为合理的膳食摄入油脂提供了理论依据。 

     

    Abstract: Imbalance of fatty acids in dietary intake is one of the main causes of inducing chronic metabolic syndrome,which threatened the health of mankind. The in vitro cellular model was employed and the evaluation indexes,including cell proliferation,cell membrane integrity,inflammatory factor,and intracellular lipid accumulation,were detected. Therefore,the dietary fatty acids,oleic acid,palmitic acid,as well as the two fatty acids' complex,were selected to assess how the excess dietary lipids influence on liver health in this work. This study demonstrated that the different dietary fatty acids exhibited different effects on liver cells.Palmitic acid shows higher cytotoxicity than oleic acid.Palmitic acid can induce cell apoptosis and disrupt the cell membrane integrity at lower doses.However,oleic acid,with the lower cytotoxicity,can cause the lipid accumulation in liver cells more easily.As far as the mixed fatty acids( oleic acid / palmitic acid,2∶ 1 ratio),although they exhibit lower cytotoxicity,inducing the lipid steatosis easily in liver cells was also observed.The experimental results for provides theory basis for reasonable dietary fat intake.

     

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