Abstract: To evaluate the effect of Douchi on the absorption of cadmium in mice,the adsorption of Douchi for heavy metal in vitro and animal experiments were carried out. The results showed that six strains of bacteria and two strains fungus were isolated from Douchi. Microbes and metabolites may cause Douchi to have good adsorption efficiency of 78.67% for cadmium in vitro. The content of cadmium in the feces of mice treated with Douchi was significantly lower than that in the control group. It indicated that Douchi promoted the absorption of cadmium in mice and aggravated the accumulation of cadmium in liver.It provided scientific basis for the reasonable edible of Douchi.