Abstract: In order to compare and analyze the quality differences of yak milk,cattle- yak milk,holstein milk and Qula made from them,three kinds of milk and Qula as the research materials,the physical and chemical properties in the milk and p H,titratable acidity,the water holding capacity,the sensory quality and texture feature of Qula in the fermentation process were investigated. The result showed that there were some differences in three kinds of milk and Qula.Total solids content of yak milk was 18.30%,protein content was 5.80%,fat content was 6.15%,being higher than that in cattle- yak milk and holstein milk( p < 0.05).Lactose content of cattle- yak milk was the highest and total solids,protein and fat content were also higher,p H,titratable acidity,the water holding capacity,the sensory quality and texture feature of cattle- yak Qula were similar to yak Qula,so cattle- milk can be the Qula raw milk to solve the problems of yak milk resource shortage to a certain extent.