Abstract: Lactobacillus growed and survived, or played a role in a variety of different environments, often subjected to a variety of stress factors and constraints.Various stresses including salt stress,freezing,heat,dry,acid stress,etc.,which inevitably resulted in damage to the lactobacillus in the process of growth,storage,preservation,etc.,and even to death. This paper reviewing the damaging mechanism of all kinds of stress on lactobacillus was not only necessary for taking appropriately protective measures to reduce the physiological damage on lactobacillus,but also providing theoretical basis for industrial production such as the production of direct-vat-starter.