Abstract: This study investigated the effects of astaxanthin esters on chronic inflammation mice fed by high fat and high fructose diet(HFFD). The model mice were established by feeding HFFD. Male C57BL/6 mice were randomly assigned into the normal control(low fat and low fructose diet),model control(HFFD),positive control(HFFD+astaxanthin,6.32 mg/kg bw·d),high dose(HFFD+astaxanthin esters,60.45mg/kg bw·d) and low dose(HFFD +astaxanthin,20.15mg/kg bw·d) groups. All animals were fed with diet and water freely for 60 days.After experiments,the white fat weight,fasting serum glucose,serum insulin,serum pro-inflammatory cytokines,such as free fatty acids(FFA),NO,reactive oxygen species(ROS),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-1β(IL-1β) and C-Reactive protein(CRP),and serum anti-inflammatory cytokines including adiponectin and interleukin- 10( IL- 10) levels were determined. Results showed that astaxanthin esters significantly decreased the white fat weight(p<0.05),Fasting serum glucose(p<0.01) and insulin levels(p<0.01),ameliorated insulin resistance(p<0.01),lowed serum pro-inflammatory cytokines FFA,NO,ROS,TNF-α,IL-6,IL-1βand CRP levels(p<0.01),and increased serum anti-inflammatory cytokines adiponectin and IL-10 levels(p <0.01). Astaxanthin esters significantly ameliorated the chronic inflammation of mice fed by HFFD and the mechanisms might involve the regulation of serum inflammation factors.