Abstract: Ultrasonic solvent extraction was used to eatarct the tannins in gallnut,and reverse- phase evaluation was used to prepare liposomes of gallnut tannins.The best technology was obtained and its physical and chemical properties were evaluated.The results showed that when the SPC / CH was 2 ∶1,the O / A was 6 ∶1,and the p H was6.5,the entrapment efficiency of liposomes prepared by gallnut tannins was 72.26%,the effective diameter was( 79.39 ± 11.62) nm and the zeta potential was-44.7 m V,the favorable storage temperature was 4℃. Preparation process of liposome using reverse- phase evaporation was simple and feasible,high encapsulation efficiency,particle size uniformity,stability and can be used for preparation of gallnut tannins liposome.