Abstract: Objective:To research the modulation effects of litchi juice on blood lipids in rats under emotional stress.Methods:Male Sprague-Dawley rats were divided into 3 groups randomly:control group, model group, litchi juice group. The rat model of emotional stress was induced by randomly giving empty water bottles. The rats were administered with saline (control group, model group) or litchi juice (litchi juice group) . 14 d later, animal behaviors were assessed in the open field test, and TG, TC, LDL-C and HDL-C were determined. Non-high density lipoprotein-cholesterol (non-HDL-C) , TG/HDL-C and LDL-C/HDL-C ratio were also calculated. Results:The body weight and food utilization rate of control group were higher than those of other groups significantly (p<0.01) .No significant differences were found for the total distance traveled and the rearing frequency in the open field among the three groups (p>0.05) . The time spent in the center and the frequency exploration towards to the center of the model group was significantly lower than those of the control and litchi juice groups (p<0.05) , and the grooming frequency of the model group was significantly higher than that of litchi juice group (p<0.05) . The plasma TC concentration of model group was significantly higher than that of control group (p<0.05) . The plasma non-HDL-C concentration of model group was significantly higher than that of the control and litchi juice groups (p<0.05) , while the LDL-C concentration of model group was significantly higher than that of control group (p<0.01) . The plasma TG/HDL-C of model group was significantly lower than that of control group (p<0.05) .The plasma HDL-C concentration of litchi juice group was significantly higher than that of control and model groups (p<0.05) . The plasma LDL-C/HDL-C of model group was significantly higher than that of control and litchi juice groups (p<0.01) . Conclusion:Litchi juice may relieve anxiety and improve blood lipids.